Display Settings:

Format

Send to:

Choose Destination
We are sorry, but NCBI web applications do not support your browser and may not function properly. More information
HomoloGene:2488. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   NKX2-1,  H.sapiens
NK2 homeobox 1
    NP_001073136.1
401 aa
   NKX2-1,  P.troglodytes
NK2 homeobox 1
    XP_509911.2
401 aa
   NKX2-1,  M.mulatta
homeobox protein Nkx-2.1-like
    XP_001089773.1
401 aa
   LOC613713,  B.taurus
NK2 homeobox 1-like
    NP_001178387.1
370 aa
   Nkx2-1,  M.musculus
NK2 homeobox 1
    NP_001139670.1
372 aa
   Nkx2-1,  R.norvegicus
NK2 homeobox 1
    NP_037225.1
372 aa
   NKX2-1,  G.gallus
NK2 homeobox 1
    NP_989947.1
344 aa
   nkx2-1,  X.tropicalis
NK2 homeobox 1
    XP_002935383.1
346 aa
   nkx2.1b,  D.rerio
NK2 homeobox 1b
    NP_571851.1
346 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Chorea, hereditary benign.
Goiter, familial, due to TTF-1 defect.
Choreoathetosis, hypothyroidism, and neonatal respiratory distress.



Publications
Articles associated with genes and sequences of this homology group.

NKX2-1-Related Disorders
Patel NJ, et al. (1993).
NKX2-1 mutation in a family diagnosed with ataxic dyskinetic cerebral palsy.
McMichael G, et al. Eur J Med Genet 56, 506-9 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
homeodomain (cl00084)
  Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Nkx2-1 includes H.sapiens NKX2-1 and R.norvegicus Nkx2-1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (8 transcripts, 8 species)
Actinopterygii - bony fishes (3 transcripts, 3 species)
Amphibia - amphibians (3 transcripts, 2 species)
Ascidiacea - tunicates (2 transcripts, 2 species)
Aves - birds (2 transcripts, 2 species)
Cephalochordata - lancelets (1 transcript, 1 species)

Arthropoda
Insecta - insects (3 transcripts, 3 species)

Platyhelminthes
Turbellaria - flatworms (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (1 transcript, 1 species)

 

 

 

Write to the Help Desk