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HomoloGene:2489. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   TTK,  H.sapiens
TTK protein kinase
    NP_003309.2
857 aa
   TTK,  P.troglodytes
TTK protein kinase
    XP_518603.2
857 aa
   LOC718430,  M.mulatta
dual specificity protein kinase TTK-like
    XP_001111082.2
857 aa
   TTK,  C.lupus
TTK protein kinase
    XP_005627621.1
854 aa
   TTK,  B.taurus
TTK protein kinase
    NP_001192842.1
856 aa
   Ttk,  M.musculus
Ttk protein kinase
    NP_033471.2
830 aa
   Ttk,  R.norvegicus
Ttk protein kinase
    NP_001101642.1
835 aa
   TTK,  G.gallus
TTK protein kinase
    XP_419867.4
880 aa
   ttk,  X.tropicalis
TTK protein kinase
    NP_001072599.1
852 aa
   ttk,  D.rerio
ttk protein kinase
    NP_778207.1
983 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

Mps1 promotes rapid centromere accumulation of Aurora B.
van der Waal MS, et al. EMBO Rep 13, 847-54 (2012).
Mps1 at kinetochores is essential for female mouse meiosis I.
Hached K, et al. Development 138, 2261-71 (2011).
Targeting the mitotic checkpoint to kill tumor cells.
Janssen A, et al. Horm Cancer 2, 113-6 (2011).
Release of Mps1 from kinetochores is crucial for timely anaphase onset.
Jelluma N, et al. J Cell Biol 191, 281-90 (2010).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
S_TKc (smart00220)
  Serine/Threonine protein kinases, catalytic domain.
Pkinase (pfam00069)
  Protein kinase domain.
TPR (cd00189)
  Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]-X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, ...
TPR (cl02429)
  Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]-X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Ttk includes H.sapiens TTK and R.norvegicus Ttk.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (13 transcripts, 10 species)
Actinopterygii - bony fishes (9 transcripts, 8 species)
Ascidiacea - tunicates (3 transcripts, 3 species)
Aves - birds (3 transcripts, 1 species)
Amniota - vertebrates (1 transcript, 1 species)

Arthropoda
Arachnida - arachnids (1 transcript, 1 species)

Mollusca
Gastropoda - gastropods (1 transcript, 1 species)

Cnidaria
Anthozoa - anthozoans (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (1 transcript, 1 species)

Streptophyta
Eudicotyledons - eudicots (2 transcripts, 2 species)
Liliopsida - monocots (1 transcript, 1 species)

 

 

 

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