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HomoloGene:2298. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   SLC18A2,  H.sapiens
solute carrier family 18 (vesicular monoamine transporter), member 2
    NP_003045.2
514 aa
   SLC18A2,  P.troglodytes
solute carrier family 18 (vesicular monoamine), member 2
    XP_521615.3
514 aa
   SLC18A2,  M.mulatta
solute carrier family 18 (vesicular monoamine), member 2
    XP_001095699.2
485 aa
   SLC18A2,  C.lupus
solute carrier family 18 (vesicular monoamine transporter), member 2
    XP_544038.2
518 aa
   SLC18A2,  B.taurus
solute carrier family 18 (vesicular monoamine), member 2
    NP_777078.1
517 aa
   Slc18a2,  M.musculus
solute carrier family 18 (vesicular monoamine), member 2
    NP_766111.1
517 aa
   Slc18a2,  R.norvegicus
solute carrier family 18 (vesicular monoamine transporter), member 2
    NP_037163.1
515 aa
   SLC18A2,  G.gallus
solute carrier family 18 (vesicular monoamine), member 2
    XP_421782.2
517 aa
   slc18a2,  D.rerio
solute carrier family 18 (vesicular monoamine), member 2
    NP_001243154.1
515 aa
   Vmat,  D.melanogaster
Vesicular monoamine transporter
    NP_001014524.1
610 aa
   AgaP_AGAP004476,  A.gambiae
AgaP_AGAP004476
    XP_313775.4
512 aa
   cat-1,  C.elegans
cat-1
    NP_001024936.1
553 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

Association of VMAT2 gene polymorphisms with alcohol dependence.
Fehr C, et al. J Neural Transm 120, 1161-9 (2013).
Analysis of vesicular monoamine transporter 2 polymorphisms in Parkinson's disease.
Brighina L, et al. Neurobiol Aging 34, 1712.e9-13 (2013).
Brain dopamine-serotonin vesicular transport disease and its treatment.
Rilstone JJ, et al. N Engl J Med 368, 543-50 (2013).
Platelet vesicular monoamine transporter 2 density in the disruptive behavior disorders.
Zalsman G, et al. J Child Adolesc Psychopharmacol 21, 341-4 (2011).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
MFS (cd06174)
  The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
Hid1 (cl15483)
  High-temperature-induced dauer-formation protein.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Slc18a2 includes H.sapiens SLC18A2 and R.norvegicus Slc18a2.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (9 transcripts, 7 species)
Amphibia - amphibians (3 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)
Ascidiacea - tunicates (1 transcript, 1 species)
Actinopterygii - bony fishes (1 transcript, 1 species)
Aves - birds (1 transcript, 1 species)

Arthropoda
Insecta - insects (9 transcripts, 7 species)
Branchiopoda - crustaceans (1 transcript, 1 species)

Platyhelminthes
Trematoda - flatworms (4 transcripts, 2 species)

Nematoda
Chromadorea - nematodes (2 transcripts, 1 species)

Mollusca
Gastropoda - gastropods (1 transcript, 1 species)

Annelida
Hirudinida - segmented worms (1 transcript, 1 species)

 

 

 

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