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HomoloGene:2534. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   VEGFA,  H.sapiens
vascular endothelial growth factor A
    NP_003367.4
395 aa
   VEGFA,  C.lupus
vascular endothelial growth factor A
    NP_001003175.2
214 aa
   VEGFA,  B.taurus
vascular endothelial growth factor A
    NP_776641.1
190 aa
   Vegfa,  M.musculus
vascular endothelial growth factor A
    NP_001020421.2
392 aa
   Vegfa,  R.norvegicus
vascular endothelial growth factor A
    NP_114024.2
393 aa
   VEGFA,  G.gallus
vascular endothelial growth factor A
    NP_990373.1
216 aa
   vegfab,  D.rerio
vascular endothelial growth factor Ab
    NP_001038320.2
233 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Diabetic retinopathy, NIDDM-related, susceptibility to.



Publications
Articles associated with genes and sequences of this homology group.

VEGF targets the tumour cell.
Goel HL & Mercurio AM. Nat Rev Cancer 13, 871-82 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
PHA02661 (PHA02661)
  vascular endothelial growth factor like protein; Provisional.
VEGF_C (pfam14554)
  VEGF heparin-binding domain.
PDGF (cl00116)
  Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a potent activator for cells of mesenchymal origin; PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer; VEGF is a potent mitogen in embryonic and ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Vegfa includes H.sapiens VEGFA and R.norvegicus Vegfa.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (16 transcripts, 13 species)
Actinopterygii - bony fishes (8 transcripts, 6 species)
Amphibia - amphibians (3 transcripts, 2 species)
Aves - birds (1 transcript, 1 species)

 

 

 

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