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HomoloGene:4115. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   SMO,  H.sapiens
smoothened, frizzled class receptor
    NP_005622.1
787 aa
   SMO,  P.troglodytes
smoothened, frizzled family receptor
    XP_519371.3
786 aa
   SMO,  M.mulatta
smoothened, frizzled family receptor
    XP_001093150.1
786 aa
   SMO,  C.lupus
smoothened, frizzled family receptor
    XP_005628462.1
697 aa
   SMO,  B.taurus
smoothened, frizzled family receptor
    NP_001179149.1
780 aa
   Smo,  M.musculus
smoothened homolog (Drosophila)
    NP_795970.3
793 aa
   Smo,  R.norvegicus
smoothened, frizzled family receptor
    NP_036939.1
793 aa
   SMO,  G.gallus
smoothened, frizzled family receptor
    XP_414970.4
695 aa
   smo,  X.tropicalis
smoothened, frizzled family receptor
    XP_002931911.2
815 aa
   smo,  D.rerio
smoothened homolog (Drosophila)
    NP_571102.1
822 aa
   smo,  D.melanogaster
smoothened
    NP_523443.1
1036 aa
   GPRSMO,  A.gambiae
GPRSMO
    XP_314720.1
1038 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Basal cell carcinoma, somatic.



Publications
Articles associated with genes and sequences of this homology group.

[Structure of the Smoothened receptor].
Ruat M, et al. Med Sci (Paris) 29, 855-60 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
7tm_2 (cl12142)
  7 transmembrane receptor (Secretin family).
7tm_2 (pfam00002)
  7 transmembrane receptor (Secretin family).
Frizzled (pfam01534)
  Frizzled/Smoothened family membrane region.
CRD_FZ (cl02447)
  CRD_domain cysteine-rich domain, also known as Fz (frizzled) domain.
CRD_FZ (cl02447)
  CRD_domain cysteine-rich domain, also known as Fz (frizzled) domain.
7tm_2 (cl19289)
  7 transmembrane receptor (Secretin family).



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Smo includes H.sapiens SMO and R.norvegicus Smo.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (10 transcripts, 9 species)
Actinopterygii - bony fishes (6 transcripts, 4 species)
Amphibia - amphibians (3 transcripts, 2 species)
Aves - birds (2 transcripts, 2 species)
Cephalochordata - lancelets (2 transcripts, 1 species)
Ascidiacea - tunicates (1 transcript, 1 species)

Arthropoda
Insecta - insects (7 transcripts, 7 species)

Annelida
Polychaeta - segmented worms (1 transcript, 1 species)

Streptophyta
Liliopsida - monocots (1 transcript, 1 species)

 

 

 

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