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HomoloGene:6659. Gene conserved in Eukaryota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   WRN,  H.sapiens
Werner syndrome, RecQ helicase-like
    NP_000544.2
1432 aa
   WRN,  P.troglodytes
Werner syndrome, RecQ helicase-like
    XP_528104.2
1432 aa
   WRN,  M.mulatta
Werner syndrome, RecQ helicase-like
    XP_001085031.1
1432 aa
   WRN,  C.lupus
Werner syndrome, RecQ helicase-like
    XP_539984.4
1417 aa
   WRN,  B.taurus
Werner syndrome, RecQ helicase-like
    NP_001137329.2
1404 aa
   Wrn,  M.musculus
Werner syndrome homolog (human)
    NP_035851.3
1401 aa
   RGD1564788,  R.norvegicus
similar to Werner syndrome helicase homolog
    XP_006253317.1
1423 aa
   WRN,  G.gallus
Werner syndrome
    XP_001235033.2
1498 aa
   wrn,  X.tropicalis
Werner syndrome, RecQ helicase-like
    XP_002939304.1
1431 aa
   wrn,  D.rerio
Werner syndrome
    XP_697980.5
1380 aa
   wrn-1,  C.elegans
wrn-1
    NP_495324.2
1056 aa
   Os07g0681600,  O.sativa
Os07g0681600
    NP_001060655.1
886 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Werner syndrome.



Publications
Articles associated with genes and sequences of this homology group.




Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
rnd (TIGR01388)
  ribonuclease D.
HELICc (cd00079)
  Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
DEXDc (cl17251)
  DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
HTH_40 (pfam14493)
  Helix-turn-helix domain.
HRDC (cl02578)
  HRDC domain.
RQC (cl09632)
  RQC domain.
DnaQ_like_exo (cl10012)
  DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily.
DEXDc (cl17251)
  DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Wrn includes H.sapiens WRN.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (7 transcripts, 7 species)
Actinopterygii - bony fishes (3 transcripts, 3 species)

Arthropoda
Insecta - insects (2 transcripts, 2 species)

Nematoda
Chromadorea - nematodes (1 transcript, 1 species)

Streptophyta
Liliopsida - monocots (3 transcripts, 3 species)
Eudicotyledons - eudicots (2 transcripts, 2 species)

 

 

 

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