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HomoloGene:36278. Gene conserved in Amniota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   AFP,  H.sapiens
alpha-fetoprotein
    NP_001125.1
609 aa
   AFP,  P.troglodytes
alpha-fetoprotein
    XP_517231.2
609 aa
   AFP,  M.mulatta
alpha-fetoprotein
    XP_001103873.1
609 aa
   AFP,  C.lupus
alpha-fetoprotein
    NP_001003027.1
609 aa
   AFP,  B.taurus
alpha-fetoprotein
    NP_001029434.1
610 aa
   Afp,  M.musculus
alpha fetoprotein
    NP_031449.3
605 aa
   Afp,  R.norvegicus
alpha-fetoprotein
    NP_036625.2
611 aa
   AFP,  G.gallus
alpha-fetoprotein
    XP_003641248.2
561 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
AFP deficiency, congenital.
Hereditary persistence of alpha-fetoprotein.



Publications
Articles associated with genes and sequences of this homology group.

Serum alpha-fetoprotein in patients with nonalcoholic fatty liver disease.
Polyzos SA & Kountouras J. Eur Rev Med Pharmacol Sci 17, 2411-2 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
ALBUMIN (cl00031)
  Albumin domain, contains five or six internal disulphide bonds; albuminoid superfamily includes alpha-fetoprotein which binds various cations, fatty acids and bilirubin; vitamin D-binding protein which binds to vitamin D, its metabolites, and fatty acids; ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Afp includes H.sapiens AFP and R.norvegicus Afp.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (14 transcripts, 12 species)

 

 

 

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