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HomoloGene:77476. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   USH1C,  H.sapiens
Usher syndrome 1C (autosomal recessive, severe)
    NP_710142.1
899 aa
   USH1C,  P.troglodytes
Usher syndrome 1C (autosomal recessive, severe)
    XP_003951893.1
901 aa
   USH1C,  C.lupus
Usher syndrome 1C (autosomal recessive, severe)
    XP_005633777.1
953 aa
   USH1C,  B.taurus
Usher syndrome 1C (autosomal recessive, severe)
    NP_001030459.1
551 aa
   Ush1c,  M.musculus
Usher syndrome 1C
    NP_710143.2
910 aa
   USH1C,  G.gallus
Usher syndrome 1C (autosomal recessive, severe)
    XP_421006.4
794 aa
   ush1c,  X.tropicalis
Usher syndrome 1C (autosomal recessive, severe)
    NP_001096522.1
541 aa
   ush1c,  D.rerio
Usher syndrome 1C (autosomal recessive, severe)
    NP_001035018.1
548 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Usher syndrome, type 1C.
Deafness, autosomal recessive 18.



Publications
Articles associated with genes and sequences of this homology group.

Novel mutations in the USH1C gene in Usher syndrome patients.
Aparisi MJ, et al. Mol Vis 16, 2948-54 (2010).
Harmonin in the murine retina and the retinal phenotypes of Ush1c-mutant mice and human USH1C.
Williams DS, et al. Invest Ophthalmol Vis Sci 50, 3881-9 (2009).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
harmonin_N (cd07353)
  N-terminal protein-binding module of harmonin.
tolA_full (TIGR02794)
  TolA protein.
ERM (pfam00769)
  Ezrin/radixin/moesin family.
Zwint (pfam15556)
  ZW10 interactor.
PDZ (cl00117)
  PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...
harmonin_N_like (cl11968)
  N-terminal protein-binding module of harmonin and similar domains, also known as HHD (harmonin homology domain).



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Ush1c includes H.sapiens USH1C and R.norvegicus Ush1c.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (11 transcripts, 11 species)
Actinopterygii - bony fishes (11 transcripts, 8 species)
Amphibia - amphibians (3 transcripts, 2 species)
Aves - birds (2 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)

Arthropoda
Arachnida - arachnids (2 transcripts, 2 species)

 

 

 

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