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HomoloGene:75168. Gene conserved in Opisthokonta Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   CHIA,  H.sapiens
chitinase, acidic
    NP_970615.2
476 aa
   CHIA,  M.mulatta
chitinase, acidic
    XP_001104487.1
474 aa
   CHIA,  C.lupus
chitinase, acidic
    XP_537030.3
483 aa
   CHIA,  B.taurus
chitinase, acidic
    NP_777124.1
472 aa
   Chia1,  M.musculus
chitinase, acidic 1
    NP_075675.2
473 aa
   Chia,  R.norvegicus
chitinase, acidic
    NP_997469.1
473 aa
   CHIA,  G.gallus
chitinase, acidic
    NP_989760.1
482 aa
   chia,  X.tropicalis
chitinase, acidic
    NP_001186489.1
482 aa
   zgc:173927,  D.rerio
zgc:173927
    NP_001103511.1
481 aa
   zgc:65788,  D.rerio
zgc:65788
    NP_955897.2
480 aa
   chia.4,  D.rerio
chitinase, acidic.4
    NP_956740.1
475 aa
   chia.3,  D.rerio
chitinase, acidic.3
    NP_998378.1
471 aa
   MGG_01247,  M.oryzae
MGG_01247
    XP_003714154.1
426 aa
   NCU03209,  N.crassa
NCU03209
    XP_965309.2
418 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

Acidic mammalian chitinase is not a critical target for allergic airway disease.
Fitz LJ, et al. Am J Respir Cell Mol Biol 46, 71-9 (2012).
Genetic association of acidic mammalian chitinase with atopic asthma and serum total IgE levels.
Chatterjee R, et al. J Allergy Clin Immunol 122, 202-8, 208.e1-7 (2008).
Pulmonary cryptococcosis induces chitinase in the rat.
Vicencio AG, et al. Respir Res 9, 40 (2008).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
CBM_14 (pfam01607)
  Chitin binding Peritrophin-A domain.
CBM_14 (cl02629)
  This domain is called the Peritrophin-A domain and is found in chitin binding proteins particularly peritrophic matrix proteins of insects and animal chitinases. Copies of the domain are also found in some baculoviruses. Relevant references that describe proteins with this domain include. It is an extracellular domain that contains six conserved cysteines that probably form three disulphide bridges. Chitin binding has been demonstrated for a protein containing only two of these domains.
GH18_chitinase-like (cl10447)
  The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Chia includes H.sapiens CHIA and R.norvegicus Chia.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Actinopterygii - bony fishes (29 transcripts, 11 species)
Mammalia - mammals (10 transcripts, 10 species)
Amphibia - amphibians (5 transcripts, 2 species)
Amniota - vertebrates (4 transcripts, 1 species)
Aves - birds (3 transcripts, 1 species)
Ascidiacea - tunicates (1 transcript, 1 species)
Cephalochordata - lancelets (1 transcript, 1 species)

Arthropoda
Insecta - insects (9 transcripts, 7 species)

Cnidaria
Hydrozoa - hydrozoans (5 transcripts, 2 species)
Anthozoa - anthozoans (1 transcript, 1 species)

Mollusca
Gastropoda - gastropods (3 transcripts, 1 species)

Annelida
Polychaeta - segmented worms (2 transcripts, 1 species)

Ascomycota
Sordariomycetes - ascomycetes (1 transcript, 1 species)

Basidiomycota
Heterobasidiomycetes - basidiomycetes (1 transcript, 1 species)

 

 

 

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