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HomoloGene:3419. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   KDM5A,  H.sapiens
lysine (K)-specific demethylase 5A
    NP_001036068.1
1690 aa
   KDM5A,  P.troglodytes
lysine (K)-specific demethylase 5A
    XP_003313474.1
1688 aa
   KDM5A,  M.mulatta
lysine (K)-specific demethylase 5A
    XP_002798486.1
1687 aa
   KDM5A,  C.lupus
lysine (K)-specific demethylase 5A
    XP_005637389.1
1688 aa
   KDM5A,  B.taurus
lysine (K)-specific demethylase 5A
    NP_001192554.1
1690 aa
   Kdm5a,  M.musculus
lysine (K)-specific demethylase 5A
    NP_666109.2
1690 aa
   Kdm5a,  R.norvegicus
lysine (K)-specific demethylase 5A
    NP_001264106.1
1690 aa
   KDM5A,  G.gallus
lysine (K)-specific demethylase 5A
    XP_004937981.1
1692 aa
   kdm5a,  X.tropicalis
lysine (K)-specific demethylase 5A
    XP_002941946.2
1718 aa
   kdm5a,  D.rerio
lysine (K)-specific demethylase 5A
    XP_003201688.2
1382 aa
   lid,  D.melanogaster
little imaginal discs
    NP_001245909.1
1838 aa
   AgaP_AGAP004854,  A.gambiae
AgaP_AGAP004854
    XP_314337.4
1494 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

The histone demethylase JARID1A regulates progesterone receptor expression.
Stratmann A & Haendler B. FEBS J 278, 1458-69 (2011).
The retinoblastoma binding protein RBP2 is an H3K4 demethylase.
Klose RJ, et al. Cell 128, 889-900 (2007).
A role for mammalian Sin3 in permanent gene silencing.
van Oevelen C, et al. Mol Cell 32, 359-70 (2008).
The trithorax-group protein Lid is a histone H3 trimethyl-Lys4 demethylase.
Lee N, et al. Nat Struct Mol Biol 14, 341-3 (2007).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
PHD (pfam00628)
  PHD-finger.
JmjC (pfam02373)
  JmjC domain, hydroxylase.
JmjN (cl15840)
  jmjN domain.
ARID (pfam01388)
  ARID/BRIGHT DNA binding domain.
zf-C5HC2 (pfam02928)
  C5HC2 zinc finger.
PLU-1 (pfam08429)
  PLU-1-like protein.
zf-C5HC2 (pfam02928)
  C5HC2 zinc finger.
PLU-1 (pfam08429)
  PLU-1-like protein.
ARID (cl02633)
  ARID/BRIGHT DNA binding domain.
PHD (cl17445)
  PHD-finger.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Kdm5a includes H.sapiens KDM5A.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (19 transcripts, 11 species)
Actinopterygii - bony fishes (10 transcripts, 8 species)
Amphibia - amphibians (2 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)
Aves - birds (1 transcript, 1 species)

Arthropoda
Insecta - insects (6 transcripts, 6 species)
Malacostraca - crustaceans (1 transcript, 1 species)

Mollusca
Gastropoda - gastropods (2 transcripts, 2 species)

Cnidaria
Hydrozoa - hydrozoans (1 transcript, 1 species)
Anthozoa - anthozoans (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (2 transcripts, 2 species)

Platyhelminthes
Trematoda - flatworms (1 transcript, 1 species)

Annelida
Polychaeta - segmented worms (1 transcript, 1 species)

Streptophyta
Eudicotyledons - eudicots (1 transcript, 1 species)
Liliopsida - monocots (1 transcript, 1 species)

Bacillariophyta
Bacillariophyceae - diatoms (1 transcript, 1 species)

 

 

 

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