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HomoloGene:68040. Gene conserved in Opisthokonta Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   GBA,  H.sapiens
glucosidase, beta, acid
    NP_001005742.1
536 aa
   GBA,  P.troglodytes
glucosidase, beta, acid
    NP_001008997.1
536 aa
   GBA,  C.lupus
glucosidase, beta, acid
    XP_855035.1
536 aa
   GBA,  B.taurus
glucosidase, beta, acid
    NP_001039886.1
536 aa
   Gba,  M.musculus
glucosidase, beta, acid
    NP_001070879.1
515 aa
   Gba,  R.norvegicus
glucosidase, beta, acid
    NP_001121111.1
515 aa
   LOC101748171,  G.gallus
glucosylceramidase-like
    XP_004950417.1
219 aa
   LOC101750375,  G.gallus
glucosylceramidase-like
    XP_004950434.1
246 aa
   gba,  D.rerio
glucosidase, beta, acid
    XP_687471.3
518 aa
   gba-3,  C.elegans
gba-3
    NP_503119.1
522 aa
   gba-1,  C.elegans
gba-1
    NP_001040750.1
523 aa
   gba-2,  C.elegans
gba-2
    NP_494208.2
516 aa
   gba-4,  C.elegans
gba-4
    NP_500785.1
519 aa
   MGG_14602,  M.oryzae
MGG_14602
    XP_003708898.1
488 aa
   NCU04395,  N.crassa
NCU04395
    XP_957472.1
480 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Gaucher disease, type I.
Gaucher disease, type II.
Gaucher disease, type III.
Gaucher disease, type IIIC.
Gaucher disease, perinatal lethal.



Publications
Articles associated with genes and sequences of this homology group.

Cholesterol glucosylation is catalyzed by transglucosylation reaction of β-glucosidase 1.
Akiyama H, et al. Biochem Biophys Res Commun 441, 838-43 (2013).
B cell lymphoma and myeloma in murine Gaucher's disease.
Pavlova EV, et al. J Pathol 231, 88-97 (2013).
A common and two novel GBA mutations in Thai patients with Gaucher disease.
Tammachote R, et al. J Hum Genet 58, 594-9 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Glyco_hydro_30 (pfam02055)
  O-Glycosyl hydrolase family 30.
Cellulase-like (cl19200)
  Sugar-binding cellulase-like.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Gba includes H.sapiens GBA.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Arthropoda
Insecta - insects (21 transcripts, 12 species)
Arachnida - arachnids (20 transcripts, 2 species)
Branchiopoda - crustaceans (1 transcript, 1 species)

Chordata
Mammalia - mammals (18 transcripts, 16 species)
Actinopterygii - bony fishes (6 transcripts, 6 species)
Ascidiacea - tunicates (4 transcripts, 2 species)
Amphibia - amphibians (2 transcripts, 2 species)
Aves - birds (1 transcript, 1 species)
Hyperoartia - vertebrates (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (8 transcripts, 2 species)

Mollusca
Gastropoda - gastropods (2 transcripts, 2 species)

Cnidaria
Anthozoa - anthozoans (1 transcript, 1 species)

Annelida
Polychaeta - segmented worms (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (1 transcript, 1 species)

Oomycetes
Peronosporales - oomycetes (5 transcripts, 1 species)
Pythiales - oomycetes (1 transcript, 1 species)

 

 

 

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