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HomoloGene:307. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   TH,  H.sapiens
tyrosine hydroxylase
    NP_954987.2
524 aa
   TH,  P.troglodytes
tyrosine hydroxylase
    XP_003312902.2
618 aa
   TH,  M.mulatta
tyrosine hydroxylase
    XP_002799487.1
454 aa
   TH,  C.lupus
tyrosine hydroxylase
    NP_001002966.1
495 aa
   TH,  B.taurus
tyrosine hydroxylase
    NP_776309.1
491 aa
   Th,  M.musculus
tyrosine hydroxylase
    NP_033403.1
498 aa
   Th,  R.norvegicus
tyrosine hydroxylase
    NP_036872.1
498 aa
   TH,  G.gallus
tyrosine hydroxylase
    NP_990136.1
491 aa
   LOC100488900,  X.tropicalis
tyrosine 3-monooxygenase-like
    XP_002938944.2
488 aa
   th,  D.rerio
tyrosine hydroxylase
    NP_571224.1
489 aa
   ple,  D.melanogaster
pale
    NP_476897.1
508 aa
   AgaP_AGAP006023,  A.gambiae
AgaP_AGAP006023
    XP_316061.3
574 aa
   cat-2,  C.elegans
cat-2
    NP_001254009.1
519 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Segawa syndrome, recessive.



Publications
Articles associated with genes and sequences of this homology group.




Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Tyr_3_monoox (TIGR01269)
  tyrosine 3-monooxygenase, tetrameric.
TOH_N (pfam12549)
  Tyrosine hydroxylase N terminal.
ACT (cl09141)
  ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme.
arom_aa_hydroxylase (cl01244)
  Biopterin-dependent aromatic amino acid hydroxylase; a family of non-heme, iron(II)-dependent enzymes that includes prokaryotic and eukaryotic phenylalanine-4-hydroxylase (PheOH), eukaryotic tyrosine hydroxylase (TyrOH) and eukaryotic tryptophan ...
ACT (cl09141)
  ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Th includes H.sapiens TH and R.norvegicus Th.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (10 transcripts, 9 species)
Actinopterygii - bony fishes (4 transcripts, 3 species)
Aves - birds (2 transcripts, 2 species)
Ascidiacea - tunicates (1 transcript, 1 species)
Cephalochordata - lancelets (1 transcript, 1 species)
Hyperoartia - vertebrates (1 transcript, 1 species)
Amphibia - amphibians (1 transcript, 1 species)

Arthropoda
Insecta - insects (13 transcripts, 12 species)
Arachnida - arachnids (1 transcript, 1 species)

Platyhelminthes
Trematoda - flatworms (2 transcripts, 2 species)

Nematoda
Chromadorea - nematodes (1 transcript, 1 species)

Streptophyta
Eudicotyledons - eudicots (1 transcript, 1 species)

 

 

 

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