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HomoloGene:4626. Gene conserved in Euteleostomi Download , Links
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

   MERTK,  H.sapiens
c-mer proto-oncogene tyrosine kinase
999 aa
   MERTK,  P.troglodytes
c-mer proto-oncogene tyrosine kinase
999 aa
   MERTK,  M.mulatta
c-mer proto-oncogene tyrosine kinase
1001 aa
   MERTK,  C.lupus
c-mer proto-oncogene tyrosine kinase
996 aa
   MERTK,  B.taurus
c-mer proto-oncogene tyrosine kinase
999 aa
   Mertk,  M.musculus
c-mer proto-oncogene tyrosine kinase
994 aa
   Mertk,  R.norvegicus
c-mer proto-oncogene tyrosine kinase
994 aa
   MERTK,  G.gallus
c-mer proto-oncogene tyrosine kinase
974 aa
   mertk,  X.tropicalis
c-mer proto-oncogene tyrosine kinase
986 aa
   mertk,  D.rerio
c-mer proto-oncogene tyrosine kinase
952 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Phenotypic information for the genes in this entry imported from model organism databases.

Retinitis pigmentosa, MERTK-related.

Articles associated with genes and sequences of this homology group.

MerTK inhibition in tumor leukocytes decreases tumor growth and metastasis.
Cook RS, et al. J Clin Invest 123, 3231-42 (2013).
MERTK receptor tyrosine kinase is a therapeutic target in melanoma.
Schlegel J, et al. J Clin Invest 123, 2257-67 (2013).

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
IG_like (smart00410)
  Immunoglobulin like.
Ig (cl11960)
  Immunoglobulin domain.
FN3 (cl00065)
  Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
PKc_like (cl09925)
  Protein Kinases, catalytic domain.
Ig (cl11960)
  Immunoglobulin domain.

Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Mertk includes H.sapiens MERTK and R.norvegicus Mertk.

Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Mammalia - mammals (11 transcripts, 9 species)
Actinopterygii - bony fishes (5 transcripts, 4 species)
Amniota - vertebrates (1 transcript, 1 species)
Aves - birds (1 transcript, 1 species)
Amphibia - amphibians (1 transcript, 1 species)




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