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HomoloGene:22738. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   SCN5A,  H.sapiens
sodium channel, voltage-gated, type V, alpha subunit
    NP_932173.1
2016 aa
   SCN5A,  P.troglodytes
sodium channel, voltage-gated, type V, alpha subunit
    XP_001171891.2
2016 aa
   LOC695085,  M.mulatta
sodium channel protein type 5 subunit alpha-like
    XP_002808375.1
2003 aa
   SCN5A,  C.lupus
sodium channel, voltage-gated, type V, alpha subunit
    NP_001002994.1
2013 aa
   SCN5A,  B.taurus
sodium channel, voltage-gated, type V, alpha subunit
    NP_776883.1
2022 aa
   Scn5a,  M.musculus
sodium channel, voltage-gated, type V, alpha
    NP_067519.2
2020 aa
   Scn5a,  R.norvegicus
sodium channel, voltage-gated, type V, alpha subunit
    NP_037257.1
2019 aa
   SCN5A,  G.gallus
sodium channel, voltage-gated, type V, alpha subunit
    XP_001232818.3
2031 aa
   scn5a,  X.tropicalis
sodium channel, voltage-gated, type V, alpha subunit
    XP_002932534.2
1981 aa
   scn12ab,  D.rerio
sodium channel, voltage gated, type XII, alpha b
    NP_001038588.1
1954 aa
   scn12aa,  D.rerio
sodium channel, voltage gated, type XII, alpha a
    NP_001038387.1
1932 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Heart block, nonprogressive.
Heart block, progressive, type I.
Brugada syndrome.
Cardiomyopathy, dilated, 1E.
Ventricular fibrillation, idiopathic.
Long QT syndrome-3.
Sick sinus syndrome.



Publications
Articles associated with genes and sequences of this homology group.

Mechanism of sodium channel NaV1.9 potentiation by G-protein signaling.
Vanoye CG, et al. J Gen Physiol 141, 193-202 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Ion_trans (pfam00520)
  Ion transport protein.
Na_trans_assoc (pfam06512)
  Sodium ion transport-associated.
DUF3451 (pfam11933)
  Domain of unknown function (DUF3451).
Na_channel_gate (cd13433)
  Inactivation gate of the voltage-gated sodium channel alpha subunits.
Ion_trans (pfam00520)
  Ion transport protein.
Na_trans_assoc (pfam06512)
  Sodium ion transport-associated.
DUF3451 (pfam11933)
  Domain of unknown function (DUF3451).
IQ (cl15479)
  Calmodulin-binding motif.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Scn5a includes H.sapiens SCN5A and R.norvegicus Scn5a.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (12 transcripts, 10 species)
Actinopterygii - bony fishes (5 transcripts, 3 species)
Amniota - vertebrates (1 transcript, 1 species)
Ascidiacea - tunicates (1 transcript, 1 species)

Arthropoda
Insecta - insects (1 transcript, 1 species)

 

 

 

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