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HomoloGene:2975. Gene conserved in Amniota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   GJB2,  H.sapiens
gap junction protein, beta 2, 26kDa
    NP_003995.2
226 aa
   GJB2,  P.troglodytes
gap junction protein, beta 2, 26kDa
    XP_522618.1
226 aa
   GJB2,  M.mulatta
gap junction protein, beta 2, 26kDa
    NP_001038200.1
226 aa
   GJB2,  C.lupus
gap junction protein, beta 2, 26kDa
    NP_001184077.1
226 aa
   GJB2,  B.taurus
gap junction protein, beta 2, 26kDa
    NP_001077106.1
226 aa
   Gjb2,  M.musculus
gap junction protein, beta 2
    NP_032151.1
226 aa
   Gjb2,  R.norvegicus
gap junction protein, beta 2
    NP_001004099.1
226 aa
   GJB2,  G.gallus
gap junction protein, beta 2, 26kDa
    NP_001257745.1
225 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Vohwinkel syndrome.
Keratitis-ichthyosis-deafness syndrome.
Keratoderma, palmoplantar, with deafness.
Bart-Pumphrey syndrome.
Deafness, autosomal recessive 1.
Deafness, autosomal dominant 3.
Hystrix-like ichthyosis with deafness.



Publications
Articles associated with genes and sequences of this homology group.

Genetics of non syndromic hearing loss in the republic of macedonia.
Sukarova Stefanovska E, et al. Balkan J Med Genet 15, 57-9 (2012).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Connexin (cl02435)
  Connexin.
Connexin_CCC (cl11207)
  Gap junction channel protein cysteine-rich domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Gjb2 includes H.sapiens GJB2 and R.norvegicus Gjb2.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (11 transcripts, 9 species)
Actinopterygii - bony fishes (5 transcripts, 3 species)
Amphibia - amphibians (3 transcripts, 2 species)
Ascidiacea - tunicates (2 transcripts, 2 species)

 

 

 

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