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HomoloGene:1449. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   GADD45A,  H.sapiens
growth arrest and DNA-damage-inducible, alpha
    NP_001915.1
165 aa
   GADD45A,  P.troglodytes
growth arrest and DNA-damage-inducible, alpha
    XP_513476.2
165 aa
   GADD45A,  M.mulatta
growth arrest and DNA-damage-inducible, alpha
    XP_001095413.1
165 aa
   GADD45A,  C.lupus
growth arrest and DNA-damage-inducible, alpha
    XP_003639149.1
164 aa
   GADD45A,  B.taurus
growth arrest and DNA-damage-inducible, alpha
    NP_001029419.1
165 aa
   Gadd45a,  M.musculus
growth arrest and DNA-damage-inducible 45 alpha
    NP_031862.1
165 aa
   Gadd45a,  R.norvegicus
growth arrest and DNA-damage-inducible, alpha
    NP_077041.2
165 aa
   GADD45A,  G.gallus
growth arrest and DNA-damage-inducible, alpha
    NP_001038143.1
157 aa
   gadd45a,  X.tropicalis
growth arrest and DNA-damage-inducible, alpha
    NP_001016151.1
157 aa
   gadd45ab,  D.rerio
growth arrest and DNA-damage-inducible, alpha, b
    NP_001002216.1
156 aa
   gadd45aa,  D.rerio
growth arrest and DNA-damage-inducible, alpha, a
    NP_956870.1
157 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

Gadd45 stress sensors in preeclampsia.
Geifman-Holtzman O, et al. Adv Exp Med Biol 793, 121-9 (2013).
Gadd45 in stress signaling, cell cycle control, and apoptosis.
Salvador JM, et al. Adv Exp Med Biol 793, 1-19 (2013).
Gadd45 proteins: relevance to aging, longevity and age-related pathologies.
Moskalev AA, et al. Ageing Res Rev 11, 51-66 (2012).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Ribosomal_L7Ae (pfam01248)
  Ribosomal protein L7Ae/L30e/S12e/Gadd45 family.
Ribosomal_L7Ae (cl00600)
  Ribosomal protein L7Ae/L30e/S12e/Gadd45 family.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Gadd45a includes H.sapiens GADD45A and R.norvegicus Gadd45a.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Actinopterygii - bony fishes (20 transcripts, 11 species)
Mammalia - mammals (11 transcripts, 10 species)
Amphibia - amphibians (3 transcripts, 2 species)
Aves - birds (2 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)

 

 

 

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