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HomoloGene:7517. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   RET,  H.sapiens
ret proto-oncogene
    NP_066124.1
1114 aa
   RET,  P.troglodytes
ret proto-oncogene
    XP_003312612.1
1285 aa
   RET,  M.mulatta
ret proto-oncogene
    XP_002805672.1
1105 aa
   RET,  C.lupus
ret proto-oncogene
    NP_001184028.1
1108 aa
   RET,  B.taurus
ret proto-oncogene
    NP_001178412.1
1072 aa
   Ret,  M.musculus
ret proto-oncogene
    NP_033076.2
1115 aa
   Ret,  R.norvegicus
ret proto-oncogene
    NP_036775.2
1115 aa
   RET,  G.gallus
ret proto-oncogene
    NP_990521.1
1064 aa
   ret,  X.tropicalis
ret proto-oncogene
    XP_002933941.2
1101 aa
   ret,  D.rerio
ret proto-oncogene receptor tyrosine kinase
    NP_858048.2
1106 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Hirschsprung disease.
Medullary thyroid carcinoma.
Multiple endocrine neoplasia IIB.
Colonic aganglionosis, total, with small bowel involvement.
Pheochromocytoma.
Multiple endocrine neoplasia IIA.
Central hypoventilation syndrome, congenital.



Publications
Articles associated with genes and sequences of this homology group.

Multiple endocrine neoplasia type 2A: case report.
Păun DL, et al. Chirurgia (Bucur) 108, 900-3 (2013).
Influence of RET mutations on the expression of tyrosine kinases in medullary thyroid carcinoma.
Rodríguez-Antona C, et al. Endocr Relat Cancer 20, 611-9 (2013).
The clinical spectrum of RET proto-oncogene mutations in codon 790.
Bihan H, et al. Eur J Endocrinol 169, 271-6 (2013).
Thyroid cancer and co-occurring RET mutations in Hirschsprung disease.
Virtanen VB, et al. Endocr Relat Cancer 20, 595-602 (2013).
Genetic analysis of a Chinese Han family with multiple endocrine neoplasia type 2A.
Guo Y, et al. Indian J Biochem Biophys 50, 26-31 (2013).
RET gene abnormalities and thyroid disease: who should be screened and when.
Salehian B & Samoa R. J Clin Res Pediatr Endocrinol 5 Suppl 1, 70-8 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
CA_like (cl15786)
  Cadherin repeat-like domain.
PKc_like (cl09925)
  Protein Kinases, catalytic domain.
CA_like (cl15786)
  Cadherin repeat-like domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Ret includes H.sapiens RET and R.norvegicus Ret.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (12 transcripts, 9 species)
Actinopterygii - bony fishes (7 transcripts, 6 species)
Amphibia - amphibians (2 transcripts, 2 species)
Aves - birds (1 transcript, 1 species)

 

 

 

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