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HomoloGene:3011. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   DCTN1,  H.sapiens
dynactin 1
    NP_004073.2
1278 aa
   DCTN1,  P.troglodytes
dynactin 1
    XP_001156535.1
1278 aa
   DCTN1,  M.mulatta
dynactin 1
    XP_001108486.2
1278 aa
   DCTN1,  C.lupus
dynactin 1
    XP_005630593.1
1276 aa
   DCTN1,  B.taurus
dynactin 1
    NP_001092404.1
1239 aa
   Dctn1,  M.musculus
dynactin 1
    NP_031861.2
1281 aa
   Dctn1,  R.norvegicus
dynactin 1
    NP_077044.1
1280 aa
   DCTN1,  G.gallus
dynactin 1
    NP_001026538.1
1224 aa
   dctn1,  X.tropicalis
dynactin 1
    XP_002936330.2
1268 aa
   dctn1b,  D.rerio
dynactin 1b
    XP_001342673.3
1275 aa
   Gl,  D.melanogaster
Glued
    NP_524061.1
1265 aa
   AgaP_AGAP004194,  A.gambiae
AgaP_AGAP004194
    XP_003436738.1
1233 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Amyotrophic lateral sclerosis, susceptibility to.
Neuropathy, distal hereditary motor, type VIIB.



Publications
Articles associated with genes and sequences of this homology group.

[Location of Dctn1 in the mouse testis and sperm and its role in spermiogenesis].
Zheng B, et al. Zhonghua Nan Ke Xue 17, 799-804 (2011).
Perry Syndrome
Wszolek Z, et al. (1993).
A genetic mosaic approach for neural circuit mapping in Drosophila.
Bohm RA, et al. Proc Natl Acad Sci U S A 107, 16378-83 (2010).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
CAP_GLY (pfam01302)
  CAP-Gly domain.
TMF_DNA_bd (pfam12329)
  TATA element modulatory factor 1 DNA binding.
Dynactin (pfam12455)
  Dynein associated protein.
COG1615 (cl09133)
  Uncharacterized conserved protein [Function unknown].
Hemagglutinin (pfam00509)
  Haemagglutinin.
DUF566 (pfam04484)
  Family of unknown function (DUF566).
Rab5-bind (pfam09311)
  Rabaptin-like protein.
Dynactin (pfam12455)
  Dynein associated protein.
DUF4600 (pfam15372)
  Domain of unknown function (DUF4600).
GrpE (cl03075)
  GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding. ...
CAP_GLY (cl08315)
  Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network. A conserved motif, CAP-Gly, has been identified in a number of CAPs, including CLIP-170 and dynactins. The crystal structure of Caenorhabditis elegans F53F4.3 protein CAP-Gly domain was recently solved. The domain contains three beta-strands. The most conserved sequence, GKNDG, is located in two consecutive sharp turns on the surface, forming the entrance to a groove.
ApoLp-III_like (cl19113)
  Apolipophorin-III and similar insect proteins.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Dctn1 includes H.sapiens DCTN1 and R.norvegicus Dctn1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Actinopterygii - bony fishes (23 transcripts, 10 species)
Mammalia - mammals (22 transcripts, 13 species)
Aves - birds (4 transcripts, 2 species)
Ascidiacea - tunicates (2 transcripts, 2 species)
Amphibia - amphibians (2 transcripts, 2 species)
Cephalochordata - lancelets (1 transcript, 1 species)

Arthropoda
Insecta - insects (7 transcripts, 7 species)
Arachnida - arachnids (1 transcript, 1 species)
Maxillopoda - crustaceans (1 transcript, 1 species)

Platyhelminthes
Trematoda - flatworms (5 transcripts, 2 species)

Echinodermata
Echinoidea - sea urchins (3 transcripts, 2 species)

Cnidaria
Hydrozoa - hydrozoans (1 transcript, 1 species)
Anthozoa - anthozoans (1 transcript, 1 species)

Annelida
Polychaeta - segmented worms (1 transcript, 1 species)
Hirudinida - segmented worms (1 transcript, 1 species)

Mollusca
Gastropoda - gastropods (1 transcript, 1 species)

Ascomycota
Sordariomycetes - ascomycetes (2 transcripts, 2 species)
Eurotiomycetes - ascomycetes (1 transcript, 1 species)

 

 

 

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