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HomoloGene:121755. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   ASIC1,  H.sapiens
acid-sensing (proton-gated) ion channel 1
    NP_064423.2
574 aa
   ACCN2,  P.troglodytes
amiloride-sensitive cation channel 2, neuronal
    XP_509053.2
574 aa
   ACCN2,  M.mulatta
acid-sensing (proton-gated) ion channel 1
    XP_002798614.1
574 aa
   ASIC1,  C.lupus
acid-sensing (proton-gated) ion channel 1
    XP_005636919.1
527 aa
   ACCN2,  B.taurus
amiloride-sensitive cation channel 2, neuronal
    NP_001179862.1
526 aa
   Asic1,  M.musculus
acid-sensing (proton-gated) ion channel 1
    NP_033727.1
526 aa
   Asic1,  R.norvegicus
acid-sensing (proton-gated) ion channel 1
    NP_077068.1
526 aa
   ACCN2,  G.gallus
amiloride-sensitive cation channel 2, neuronal
    NP_001035557.1
527 aa
   asic1,  X.tropicalis
acid-sensing (proton-gated) ion channel 1
    XP_002935779.1
525 aa
   asic1a,  D.rerio
acid-sensing (proton-gated) ion channel 1a
    NP_999955.1
501 aa
   del-10,  C.elegans
del-10
    NP_495302.3
1069 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

Role of ASIC1 in the development of chronic hypoxia-induced pulmonary hypertension.
Nitta CH, et al. Am J Physiol Heart Circ Physiol 306, H41-52 (2014).
Gating transitions in the palm domain of ASIC1a.
Della Vecchia MC, et al. J Biol Chem 288, 5487-95 (2013).
Acid-sensing ion channels in pathological conditions.
Chu XP & Xiong ZG. Adv Exp Med Biol 961, 419-31 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
ASC (pfam00858)
  Amiloride-sensitive sodium channel.
ASC (cl02990)
  Amiloride-sensitive sodium channel.
ASC (cl02990)
  Amiloride-sensitive sodium channel.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Asic1 includes H.sapiens ASIC1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (11 transcripts, 9 species)
Actinopterygii - bony fishes (6 transcripts, 5 species)
Amphibia - amphibians (3 transcripts, 2 species)
Aves - birds (2 transcripts, 1 species)

 

 

 

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