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HomoloGene:8160. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   SCAP,  H.sapiens
SREBF chaperone
    NP_036367.2
1279 aa
   SCAP,  P.troglodytes
SREBF chaperone
    XP_003950140.1
1066 aa
   SCAP,  M.mulatta
SREBF chaperone
    XP_001100342.2
1229 aa
   SCAP,  C.lupus
SREBF chaperone
    XP_541898.2
1261 aa
   SCAP,  B.taurus
SREBF chaperone
    NP_001095359.1
1278 aa
   Scap,  M.musculus
SREBF chaperone
    NP_001096632.1
1276 aa
   Scap,  R.norvegicus
SREBF chaperone
    NP_001094436.1
1276 aa
   SCAP,  G.gallus
SREBF chaperone
    XP_001231540.3
1316 aa
   scap,  X.tropicalis
SREBF chaperone
    NP_001120162.1
1319 aa
   LOC558292,  D.rerio
sterol regulatory element-binding protein cleavage-activating protein-like
    XP_005158307.1
1294 aa
   SCAP,  D.melanogaster
SREBP cleavage activating protein
    NP_788277.1
1276 aa
   AgaP_AGAP011336,  A.gambiae
AgaP_AGAP011336
    XP_309314.4
1274 aa
   scp-1,  C.elegans
scp-1
    NP_001022051.1
1087 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

SCAP is required for timely and proper myelin membrane synthesis.
Verheijen MH, et al. Proc Natl Acad Sci U S A 106, 21383-8 (2009).
Cholesterol, hydroxycholesterols, and bile acids.
Javitt NB. Biochem Biophys Res Commun 292, 1147-53 (2002).
SCAP ligands are potent new lipid-lowering drugs.
Grand-Perret T, et al. Nat Med 7, 1332-8 (2001).
A new feature on the cholesterol-lowering landscape.
Rader DJ. Nat Med 7, 1282-4 (2001).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Sterol-sensing (pfam12349)
  Sterol-sensing domain of SREBP cleavage-activation.
WD40 (cd00200)
  WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
WD40 (cl02567)
  WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
Sterol-sensing (pfam12349)
  Sterol-sensing domain of SREBP cleavage-activation.
WD40 (cl02567)
  Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Scap includes H.sapiens SCAP and R.norvegicus Scap.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (17 transcripts, 11 species)
Actinopterygii - bony fishes (5 transcripts, 3 species)
Amphibia - amphibians (2 transcripts, 2 species)
Aves - birds (1 transcript, 1 species)

Arthropoda
Insecta - insects (7 transcripts, 6 species)

Nematoda
Chromadorea - nematodes (1 transcript, 1 species)

Platyhelminthes
Trematoda - flatworms (1 transcript, 1 species)

Basidiomycota
Heterobasidiomycetes - basidiomycetes (1 transcript, 1 species)

 

 

 

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