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HomoloGene:13060. Gene conserved in Boreoeutheria Download , Links
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

   HCAR1,  H.sapiens
hydroxycarboxylic acid receptor 1
346 aa
   HCAR1,  P.troglodytes
hydroxycarboxylic acid receptor 1
346 aa
   HCAR1,  M.mulatta
hydroxycarboxylic acid receptor 1
337 aa
   HCAR1,  C.lupus
hydroxycarboxylic acid receptor 1
362 aa
   HCAR1,  B.taurus
hydroxycarboxylic acid receptor 1
335 aa
   Gpr81,  M.musculus
G protein-coupled receptor 81
351 aa
   Gpr81,  R.norvegicus
G protein-coupled receptor 81
351 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Articles associated with genes and sequences of this homology group.

Biological and pharmacological roles of HCA receptors.
Blad CC, et al. Adv Pharmacol 62, 219-50 (2011).
Inflammation inhibits GPR81 expression in adipose tissue.
Feingold KR, et al. Inflamm Res 60, 991-5 (2011).
Effects of high fat diet on GPR109A and GPR81 gene expression.
Wanders D, et al. Biochem Biophys Res Commun 425, 278-83 (2012).
Role of GPR81 in lactate-mediated reduction of adipose lipolysis.
Cai TQ, et al. Biochem Biophys Res Commun 377, 987-91 (2008).

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
7tm_1 (pfam00001)
  7 transmembrane receptor (rhodopsin family).
7tm_1 (pfam00001)
  7 transmembrane receptor (rhodopsin family).

Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Gpr81 includes H.sapiens HCAR1 and R.norvegicus Gpr81.

Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Mammalia - mammals (7 transcripts, 6 species)




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