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HomoloGene:298. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

ABCA4,  H.sapiens
ATP-binding cassette, sub-family A (ABC1), member 4
NP_000341.2
2273 aa
ABCA4,  P.troglodytes
ATP-binding cassette, sub-family A (ABC1), member 4
XP_001152577.2
2273 aa
ABCA4,  M.mulatta
retinal-specific ATP-binding cassette transporter-like
XP_002808277.1
2345 aa
ABCA4,  C.lupus
ATP-binding cassette, sub-family A (ABC1), member 4
NP_001003360.2
2269 aa
ABCA4,  B.taurus
ATP-binding cassette, sub-family A (ABC1), member 4
NP_776646.1
2281 aa
Abca4,  M.musculus
ATP-binding cassette, sub-family A (ABC1), member 4
NP_031404.1
2310 aa
Abca4,  R.norvegicus
ATP-binding cassette, subfamily A (ABC1), member 4
NP_001101191.1
2290 aa
ABCA4,  G.gallus
ATP-binding cassette, sub-family A (ABC1), member 4
XP_422330.3
2275 aa
abca4,  X.tropicalis
ATP-binding cassette, sub-family A (ABC1), member 4
NP_001011033.1
2359 aa
abca4b,  D.rerio
ATP-binding cassette, sub-family A (ABC1), member 4b
XP_683123.5
2327 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Macular degeneration, age-related, 2.
Fundus flavimaculatus.
Stargardt disease-1.
Retinitis pigmentosa-19.
Cone-rod dystrophy 3.



Publications
Articles associated with genes and sequences of this homology group.

ABCA4 gene screening by next-generation sequencing in a British cohort.
Fujinami K, et al. Invest Ophthalmol Vis Sci 54, 6662-74 (2013).
The clinical effect of homozygous ABCA4 alleles in 18 patients.
Fujinami K, et al. Ophthalmology 120, 2324-31 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
ABC2_membrane_3 (pfam12698)
  ABC-2 family transporter protein.
ABC_ATPase (cl17201)
  ATP-binding cassette transporter nucleotide-binding domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Abca4 includes H.sapiens ABCA4 and R.norvegicus Abca4.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (9 transcripts, 8 species)
Actinopterygii - bony fishes (8 transcripts, 4 species)
Amphibia - amphibians (2 transcripts, 2 species)
Aves - birds (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (1 transcript, 1 species)

 

 

 

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