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HomoloGene:76699. Gene conserved in Eukaryota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   CTSV,  H.sapiens
cathepsin V
    NP_001324.2
334 aa
   CTSL2,  P.troglodytes
cathepsin L2
    XP_520130.2
334 aa
   CTSL2,  M.mulatta
cathepsin L2
    XP_002800251.1
334 aa
   LOC102156614,  C.lupus
cathepsin L1-like
    XP_005615836.1
333 aa
   CTSL,  C.lupus
cathepsin L2
    NP_001239115.1
333 aa
   CTSV,  B.taurus
cathepsin L2
    NP_776457.1
334 aa
   Ctsl,  M.musculus
cathepsin L
    NP_034114.1
334 aa
   Ctsl1,  R.norvegicus
cathepsin L1
    NP_037288.1
334 aa
   CTSL2,  G.gallus
cathepsin L2
    NP_001161481.1
353 aa
   ctsv,  X.tropicalis
cathepsin V
    NP_001004869.1
335 aa
   ctsla,  D.rerio
cathepsin La
    NP_997749.1
337 aa
   Cp1,  D.melanogaster
Cysteine proteinase-1
    NP_523735.2
371 aa
   AgaP_AGAP011828,  A.gambiae
AgaP_AGAP011828
    XP_001689282.1
344 aa
   cpl-1,  C.elegans
cpl-1
    NP_001256718.1
337 aa
   AT3G19390,  A.thaliana
AT3G19390
    NP_566633.1
452 aa
   RD21,  A.thaliana
RD21
    NP_564497.1
462 aa
   AT5G43060,  A.thaliana
AT5G43060
    NP_568620.1
463 aa
   AT3G19400,  A.thaliana
AT3G19400
    NP_566634.2
362 aa
   AT3G43960,  A.thaliana
AT3G43960
    NP_566867.1
376 aa
   Os04g0670500,  O.sativa
Os04g0670500
    NP_001054213.1
490 aa
   Os04g0670200,  O.sativa
Os04g0670200
    NP_001054211.2
466 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

B-cell lymphopoiesis is regulated by cathepsin L.
Badano MN, et al. PLoS One 8, e61347 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Inhibitor_I29 (pfam08246)
  Cathepsin propeptide inhibitor domain (I29).
Peptidase_C1 (cl00298)
  C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some ...
Granulin (cl02546)
  Granulin.
Inhibitor_I29 (cl07031)
  Cathepsin propeptide inhibitor domain (I29).



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Ctsl includes H.sapiens CTSL1 and R.norvegicus Ctsl1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Actinopterygii - bony fishes (36 transcripts, 12 species)
Mammalia - mammals (35 transcripts, 16 species)
Cephalochordata - lancelets (11 transcripts, 1 species)
Amphibia - amphibians (9 transcripts, 2 species)
Ascidiacea - tunicates (4 transcripts, 3 species)
Aves - birds (4 transcripts, 3 species)
Hyperoartia - vertebrates (4 transcripts, 1 species)
Amniota - vertebrates (1 transcript, 1 species)

Arthropoda
Insecta - insects (30 transcripts, 13 species)
Arachnida - arachnids (13 transcripts, 2 species)
Malacostraca - crustaceans (4 transcripts, 1 species)
Maxillopoda - crustaceans (3 transcripts, 1 species)
Branchiopoda - crustaceans (2 transcripts, 1 species)

Platyhelminthes
Turbellaria - flatworms (11 transcripts, 1 species)
Trematoda - flatworms (10 transcripts, 2 species)

Cnidaria
Hydrozoa - hydrozoans (15 transcripts, 2 species)
Anthozoa - anthozoans (4 transcripts, 1 species)

Mollusca
Gastropoda - gastropods (13 transcripts, 2 species)

Porifera
Demospongiae - sponges (7 transcripts, 1 species)

Echinodermata
Echinoidea - sea urchins (6 transcripts, 2 species)

Annelida
Polychaeta - segmented worms (3 transcripts, 1 species)
Hirudinida - segmented worms (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (3 transcripts, 2 species)

Streptophyta
Eudicotyledons - eudicots (51 transcripts, 25 species)
Liliopsida - monocots (30 transcripts, 9 species)
Coniferopsida - conifers (15 transcripts, 3 species)

Chlorophyta
Chlorophyceae - green algae (5 transcripts, 2 species)

Ciliophora
Oligohymenophorea - ciliates (18 transcripts, 2 species)

Apicomplexa
Coccidia - apicomplexans (1 transcript, 1 species)

Dictyosteliida
Dictyostelium - cellular slime molds (5 transcripts, 1 species)

Codonosigidae
Monosiga - choanoflagellates (5 transcripts, 1 species)

Bacillariophyta
Bacillariophyceae - diatoms (2 transcripts, 1 species)

Oomycetes
Pythiales - oomycetes (2 transcripts, 1 species)

Ascomycota
Sordariomycetes - ascomycetes (1 transcript, 1 species)
Eurotiomycetes - ascomycetes (1 transcript, 1 species)

 

 

 

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