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HomoloGene:73. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   COL7A1,  H.sapiens
collagen, type VII, alpha 1
    NP_000085.1
2944 aa
   COL7A1,  P.troglodytes
collagen, type VII, alpha 1
    XP_003950149.1
2944 aa
   COL7A1,  C.lupus
collagen, type VII, alpha 1
    NP_001002980.1
2936 aa
   COL7A1,  B.taurus
collagen, type VII, alpha 1
    XP_002697097.2
2930 aa
   Col7a1,  M.musculus
collagen, type VII, alpha 1
    NP_031764.2
2944 aa
   Col7a1,  R.norvegicus
collagen, type VII, alpha 1
    NP_001100328.1
2588 aa
   COL7A1,  G.gallus
collagen, type VII, alpha 1
    XP_425157.4
3002 aa
   col7a1,  X.tropicalis
collagen, type VII, alpha 1
    XP_002933125.2
3003 aa
   col7a1,  D.rerio
collagen, type VII, alpha 1
    XP_002662551.3
1923 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
EBD, localisata variant.
Transient bullous of the newborn.
Epidermolysis bullosa dystrophica, AD.
Epidermolysis bullosa, pretibial.
EBD, Bart type.
Epidermolysis bullosa dystrophica, AR.
Epidermolysis bullosa pruriginosa.
Toenail dystrophy, isolated.



Publications
Articles associated with genes and sequences of this homology group.

Collagen VII plays a dual role in wound healing.
Nyström A, et al. J Clin Invest 123, 3498-509 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
fn3 (pfam00041)
  Fibronectin type III domain.
FN3 (cl00065)
  Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
vWFA (cl00057)
  Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
vWFA (cl00057)
  Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
FN3 (cl00065)
  Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
KU (cl00101)
  BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
Collagen (cl19732)
  Collagen triple helix repeat (20 copies).



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Col7a1 includes H.sapiens COL7A1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (11 transcripts, 7 species)

 

 

 

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