Display Settings:

Format

Send to:

Choose Destination
We are sorry, but NCBI web applications do not support your browser and may not function properly. More information
HomoloGene:4122. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   SYT1,  H.sapiens
synaptotagmin I
    NP_001129278.1
422 aa
   SYT1,  P.troglodytes
synaptotagmin I
    XP_001162865.1
422 aa
   SYT1,  M.mulatta
synaptotagmin I
    XP_001084494.2
430 aa
   SYT1,  C.lupus
synaptotagmin I
    XP_539696.2
422 aa
   SYT1,  B.taurus
synaptotagmin I
    NP_776617.1
422 aa
   Syt1,  M.musculus
synaptotagmin I
    NP_001239270.1
421 aa
   Syt1,  R.norvegicus
synaptotagmin I
    NP_001028852.2
421 aa
   SYT1,  G.gallus
synaptotagmin I
    NP_990502.1
424 aa
   syt1,  X.tropicalis
synaptotagmin 1
    XP_004913017.1
425 aa
   Syt1,  D.melanogaster
Synaptotagmin 1
    NP_722839.1
472 aa
   AgaP_AGAP007942,  A.gambiae
AgaP_AGAP007942
    XP_317535.4
448 aa
   snt-1,  C.elegans
snt-1
    NP_495394.3
443 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

Synaptotagmin 1 is required for vesicular Ca²⁺/H⁺-antiport activity.
Cordeiro JM, et al. J Neurochem 126, 37-46 (2013).
Fusion pore formation and expansion induced by Ca2+ and synaptotagmin 1.
Lai Y, et al. Proc Natl Acad Sci U S A 110, 1333-8 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
C2 (cl14603)
  C2 domain.
C2 (cl14603)
  C2 domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Syt1 includes H.sapiens SYT1 and R.norvegicus Syt1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (15 transcripts, 10 species)
Actinopterygii - bony fishes (14 transcripts, 6 species)
Amniota - vertebrates (3 transcripts, 1 species)
Amphibia - amphibians (3 transcripts, 2 species)
Aves - birds (2 transcripts, 2 species)
Ascidiacea - tunicates (1 transcript, 1 species)
Cephalochordata - lancelets (1 transcript, 1 species)

Arthropoda
Insecta - insects (13 transcripts, 11 species)
Arachnida - arachnids (2 transcripts, 1 species)

Platyhelminthes
Turbellaria - flatworms (3 transcripts, 1 species)
Trematoda - flatworms (2 transcripts, 2 species)

Nematoda
Chromadorea - nematodes (3 transcripts, 2 species)

Mollusca
Gastropoda - gastropods (2 transcripts, 2 species)

Annelida
Polychaeta - segmented worms (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (1 transcript, 1 species)

 

 

 

Write to the Help Desk