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HomoloGene:11311. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   DNAI2,  H.sapiens
dynein, axonemal, intermediate chain 2
    NP_075462.3
605 aa
   DNAI2,  P.troglodytes
dynein, axonemal, intermediate chain 2
    XP_003953226.1
605 aa
   DNAI2,  M.mulatta
dynein, axonemal, intermediate chain 2
    XP_001088046.2
596 aa
   DNAI2,  C.lupus
dynein, axonemal, intermediate chain 2
    XP_540403.3
598 aa
   DNAI2,  B.taurus
dynein, axonemal, intermediate chain 2
    XP_005221385.1
617 aa
   Dnaic2,  M.musculus
dynein, axonemal, intermediate chain 2
    NP_001030050.2
623 aa
   Dnai2,  R.norvegicus
dynein, axonemal, intermediate chain 2
    NP_001007727.1
619 aa
   DNAI2,  G.gallus
dynein, axonemal, intermediate chain 2
    XP_415701.2
608 aa
   dnai2,  X.tropicalis
dynein, axonemal, intermediate chain 2
    XP_002935429.1
587 aa
   LOC101884977,  D.rerio
dynein intermediate chain 3, ciliary-like
    XP_005156459.1
604 aa
   CG6053,  D.melanogaster
CG6053
    NP_001261723.1
585 aa
   AgaP_AGAP011539,  A.gambiae
AgaP_AGAP011539
    XP_309969.4
537 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Ciliary dyskinesia, primary, 9, with our without situs inversus.



Publications
Articles associated with genes and sequences of this homology group.

Mouse dynein axonemal intermediate chain 2: cloning and expression.
Yang Z & Wu J. DNA Cell Biol 27, 479-88 (2008).
Primary ciliary dyskinesia: genes, candidate genes and chromosomal regions.
Geremek M & Witt M. J Appl Genet 45, 347-61 (2004).
A unified taxonomy for ciliary dyneins.
Hom EF, et al. Cytoskeleton (Hoboken) 68, 555-65 (2011).
Primary Ciliary Dyskinesia
Zariwala MA, et al. (1993).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
COG2319 (COG2319)
  FOG: WD40 repeat [General function prediction only].
tolA_full (TIGR02794)
  TolA protein.
WD40 (cl02567)
  WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Dnaic2 includes H.sapiens DNAI2 and R.norvegicus Dnai2.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Actinopterygii - bony fishes (11 transcripts, 7 species)
Mammalia - mammals (9 transcripts, 7 species)
Ascidiacea - tunicates (2 transcripts, 2 species)
Amphibia - amphibians (2 transcripts, 2 species)
Aves - birds (1 transcript, 1 species)
Cephalochordata - lancelets (1 transcript, 1 species)

Arthropoda
Insecta - insects (5 transcripts, 4 species)
Maxillopoda - crustaceans (1 transcript, 1 species)

Platyhelminthes
Trematoda - flatworms (2 transcripts, 2 species)
Turbellaria - flatworms (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (3 transcripts, 2 species)

Mollusca
Gastropoda - gastropods (2 transcripts, 2 species)

Cnidaria
Hydrozoa - hydrozoans (1 transcript, 1 species)
Anthozoa - anthozoans (1 transcript, 1 species)

Porifera
Demospongiae - sponges (1 transcript, 1 species)

Oomycetes
Peronosporales - oomycetes (1 transcript, 1 species)

Ciliophora
Oligohymenophorea - ciliates (1 transcript, 1 species)

Codonosigidae
Monosiga - choanoflagellates (1 transcript, 1 species)

 

 

 

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