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HomoloGene:68318. Gene conserved in Eukaryota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   CHIT1,  H.sapiens
chitinase 1 (chitotriosidase)
    NP_003456.1
466 aa
   CHIT1,  P.troglodytes
chitinase 1 (chitotriosidase)
    XP_001155147.2
476 aa
   CHIT1,  M.mulatta
chitinase 1 (chitotriosidase)
    XP_001103012.1
466 aa
   CHIT1,  B.taurus
chitinase 1 (chitotriosidase)
    XP_003587088.2
481 aa
   Chit1,  M.musculus
chitinase 1 (chitotriosidase)
    NP_001271454.1
464 aa
   Chit1,  R.norvegicus
chitinase 1 (chitotriosidase)
    NP_001257775.1
464 aa
   chit1,  X.tropicalis
chitinase 1 (chitotriosidase)
    NP_001005792.1
492 aa
   Cht7,  D.melanogaster
Cht7
    NP_647768.3
1013 aa
   AgaP_AGAP006898,  A.gambiae
AgaP_AGAP006898
    XP_308858.4
1017 aa
   cht-1,  C.elegans
cht-1
    NP_508588.1
617 aa
   MGG_05533,  M.oryzae
MGG_05533
    XP_003710401.1
436 aa
   AT4G19810,  A.thaliana
AT4G19810
    NP_193716.1
379 aa
   AT4G19720,  A.thaliana
AT4G19720
    NP_193707.2
363 aa
   AT4G19730,  A.thaliana
AT4G19730
    NP_193708.1
332 aa
   AT4G19760,  A.thaliana
AT4G19760
    NP_193711.2
369 aa
   AT4G19740,  A.thaliana
AT4G19740
    NP_193709.3
211 aa
   AT4G19750,  A.thaliana
AT4G19750
    NP_193710.2
362 aa
   AT4G19800,  A.thaliana
AT4G19800
    NP_193715.1
398 aa
   AT4G19770,  A.thaliana
AT4G19770
    NP_193712.2
261 aa
   AT4G19820,  A.thaliana
AT4G19820
    NP_193717.1
366 aa
   Os11g0462100,  O.sativa
Os11g0462100
    NP_001067864.1
451 aa
   Os04g0376400,  O.sativa
Os04g0376400
    NP_001052581.1
479 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Chitotriosidase deficiency.



Publications
Articles associated with genes and sequences of this homology group.

Analysis of productive binding modes in the human chitotriosidase.
Eide KB, et al. FEBS Lett 587, 3508-13 (2013).
Association of genetic variation in chitotriosidase with atopy in Korean children.
Kim KW, et al. Ann Allergy Asthma Immunol 110, 444-449.e1 (2013).
[24-bp duplication on CHIT1 gene in Mexican population].
Juárez-Rendón KJ, et al. Rev Med Inst Mex Seguro Soc 50, 375-7 (2012).
Serum chitotriosidase activity in acute coronary syndrome.
Yildiz BS, et al. J Atheroscler Thromb 20, 134-41 (2013).
Human chitotriosidase-catalyzed hydrolysis of chitosan.
Eide KB, et al. Biochemistry 51, 487-95 (2012).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
CBM_14 (pfam01607)
  Chitin binding Peritrophin-A domain.
GH18_chitinase-like (cl10447)
  The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have ...
CBM_14 (cl02629)
  This domain is called the Peritrophin-A domain and is found in chitin binding proteins particularly peritrophic matrix proteins of insects and animal chitinases. Copies of the domain are also found in some baculoviruses. Relevant references that describe proteins with this domain include. It is an extracellular domain that contains six conserved cysteines that probably form three disulphide bridges. Chitin binding has been demonstrated for a protein containing only two of these domains.
GH18_chitinase-like (cl10447)
  The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Chit1 includes H.sapiens CHIT1 and R.norvegicus Chit1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Arthropoda
Insecta - insects (20 transcripts, 8 species)
Branchiopoda - crustaceans (1 transcript, 1 species)

Chordata
Mammalia - mammals (8 transcripts, 8 species)
Actinopterygii - bony fishes (2 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)
Ascidiacea - tunicates (1 transcript, 1 species)

Mollusca
Gastropoda - gastropods (5 transcripts, 2 species)

Cnidaria
Hydrozoa - hydrozoans (4 transcripts, 2 species)

Annelida
Polychaeta - segmented worms (2 transcripts, 1 species)

Nematoda
Chromadorea - nematodes (1 transcript, 1 species)

Streptophyta
Eudicotyledons - eudicots (22 transcripts, 14 species)
Liliopsida - monocots (4 transcripts, 3 species)

Ascomycota
Eurotiomycetes - ascomycetes (4 transcripts, 1 species)
Sordariomycetes - ascomycetes (1 transcript, 1 species)

 

 

 

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