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HomoloGene:210. Gene conserved in Eukaryota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   MSH2,  H.sapiens
mutS homolog 2
    NP_000242.1
934 aa
   MSH2,  C.lupus
mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli)
    XP_538482.2
934 aa
   MSH2,  B.taurus
mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli)
    NP_001029756.1
934 aa
   Msh2,  M.musculus
mutS homolog 2 (E. coli)
    NP_032654.1
935 aa
   Msh2,  R.norvegicus
mutS homolog 2
    NP_112320.1
933 aa
   MSH2,  G.gallus
mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli)
    XP_426110.4
968 aa
   msh2,  X.tropicalis
mutS homolog 2
    XP_002935427.2
932 aa
   msh2,  D.rerio
mutS homolog 2 (E. coli)
    NP_998689.1
936 aa
   spel1,  D.melanogaster
spellchecker1
    NP_001246031.1
917 aa
   AgaP_AGAP010282,  A.gambiae
AgaP_AGAP010282
    XP_319476.4
881 aa
   MSH2,  S.cerevisiae
MSH2
    NP_014551.1
964 aa
   KLLA0F02706g,  K.lactis
KLLA0F02706g
    XP_455202.1
956 aa
   AGOS_AFR603C,  E.gossypii
AGOS_AFR603C
    NP_986150.1
956 aa
   msh2,  S.pombe
msh2
    XP_001713136.1
982 aa
   MGG_00879,  M.oryzae
MGG_00879
    XP_003718090.1
924 aa
   NCU02230,  N.crassa
NCU02230
    XP_959643.1
937 aa
   MSH2,  A.thaliana
MSH2
    NP_566804.3
937 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Cafe-au-lait spots, multiple, with leukemia.
Lynch cancer family syndrome II.
Colorectal cancer, hereditary nonpolyposis, type 1.
Glioblastoma, early-onset.
Muir-Torre syndrome.
Neurofibromatosis, type I, with leukemia.
Lymphoma, T-cell.
Ovarian cancer.



Publications
Articles associated with genes and sequences of this homology group.

The hMSH2(M688R) Lynch syndrome mutation may function as a dominant negative.
Martín-López JV, et al. Carcinogenesis 33, 1647-54 (2012).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
MUTSd (smart00533)
  DNA-binding domain of DNA mismatch repair MUTS family.
MutS_V (pfam00488)
  MutS domain V.
MutS_I (pfam01624)
  MutS domain I.
MutS_III (pfam05192)
  MutS domain III.
MutS_II (pfam05188)
  MutS domain II.
MutS_I (pfam01624)
  MutS domain I.
MutS_II (pfam05188)
  MutS domain II.
ABC_ATPase (cl17201)
  ATP-binding cassette transporter nucleotide-binding domain.
MutS_III (cl17822)
  This domain is found in proteins of the MutS family (DNA mismatch repair proteins) and is found associated with pfam00488, pfam05188, pfam01624 and pfam05190. The MutS family of proteins is named after the Salmonella typhimurium MutS protein involved in mismatch repair; other members of the family included the eukaryotic MSH 1,2,3, 4,5 and 6 proteins. These have various roles in DNA repair and recombination. Human MSH has been implicated in non-polyposis colorectal carcinoma (HNPCC) and is a mismatch binding protein. The aligned region corresponds with domain III, which is central to the structure of Thermus aquaticus MutS as characterized in.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Msh2 includes H.sapiens MSH2 and R.norvegicus Msh2.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (15 transcripts, 12 species)
Actinopterygii - bony fishes (10 transcripts, 9 species)
Ascidiacea - tunicates (3 transcripts, 3 species)
Amphibia - amphibians (3 transcripts, 2 species)
Aves - birds (2 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)

Arthropoda
Insecta - insects (8 transcripts, 8 species)
Branchiopoda - crustaceans (1 transcript, 1 species)
Maxillopoda - crustaceans (1 transcript, 1 species)

Cnidaria
Hydrozoa - hydrozoans (2 transcripts, 1 species)
Anthozoa - anthozoans (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (3 transcripts, 2 species)

Platyhelminthes
Trematoda - flatworms (2 transcripts, 2 species)

Annelida
Polychaeta - segmented worms (1 transcript, 1 species)
Hirudinida - segmented worms (1 transcript, 1 species)

Mollusca
Gastropoda - gastropods (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (1 transcript, 1 species)

Streptophyta
Eudicotyledons - eudicots (17 transcripts, 13 species)
Liliopsida - monocots (8 transcripts, 7 species)
Bryopsida - mosses (1 transcript, 1 species)
Coniferopsida - conifers (1 transcript, 1 species)

Ascomycota
Sordariomycetes - ascomycetes (2 transcripts, 2 species)
Eurotiomycetes - ascomycetes (1 transcript, 1 species)

Basidiomycota
Heterobasidiomycetes - basidiomycetes (1 transcript, 1 species)

Oomycetes
Peronosporales - oomycetes (1 transcript, 1 species)
Pythiales - oomycetes (1 transcript, 1 species)

Apicomplexa
Coccidia - apicomplexans (1 transcript, 1 species)

Ciliophora
Oligohymenophorea - ciliates (1 transcript, 1 species)

Dictyosteliida
Dictyostelium - cellular slime molds (1 transcript, 1 species)

 

 

 

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