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HomoloGene:31234. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   ASCL1,  H.sapiens
achaete-scute family bHLH transcription factor 1
    NP_004307.2
236 aa
   ASCL1,  P.troglodytes
achaete-scute complex homolog 1 (Drosophila)
    XP_003954517.1
268 aa
   ASCL1,  M.mulatta
achaete-scute complex homolog 1 (Drosophila)
    XP_001094978.1
238 aa
   ASCL1,  C.lupus
achaete-scute complex homolog 1 (Drosophila)
    XP_539745.3
240 aa
   ASCL1,  B.taurus
achaete-scute complex homolog 1 (Drosophila)
    XP_002687686.1
219 aa
   Ascl1,  M.musculus
achaete-scute complex homolog 1 (Drosophila)
    NP_032579.2
231 aa
   Ascl1,  R.norvegicus
achaete-scute family bHLH transcription factor 1
    NP_071779.1
233 aa
   ascl1,  X.tropicalis
achaete-scute complex homolog 1 (Drosophila)
    XP_002944648.2
198 aa
   ascl1a,  D.rerio
achaete-scute complex-like 1a (Drosophila)
    NP_571294.1
196 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Central hypoventilation syndrome, congenital.
Haddad syndrome.



Publications
Articles associated with genes and sequences of this homology group.

ASCL1 reprograms mouse Muller glia into neurogenic retinal progenitors.
Pollak J, et al. Development 140, 2619-31 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
HLH (cl00081)
  Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Ascl1 includes H.sapiens ASCL1 and R.norvegicus Ascl1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (9 transcripts, 8 species)
Actinopterygii - bony fishes (8 transcripts, 5 species)
Amphibia - amphibians (3 transcripts, 2 species)
Aves - birds (2 transcripts, 1 species)

Arthropoda
Insecta - insects (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (1 transcript, 1 species)

 

 

 

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