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HomoloGene:7564. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   TCF7L2,  H.sapiens
transcription factor 7-like 2 (T-cell specific, HMG-box)
    NP_110383.2
596 aa
   TCF7L2,  P.troglodytes
transcription factor 7-like 2 (T-cell specific, HMG-box)
    XP_003951826.1
705 aa
   LOC701759,  M.mulatta
transcription factor 7-like 2-like
    XP_001090054.2
541 aa
   TCF7L2,  C.lupus
transcription factor 7-like 2 (T-cell specific, HMG-box)
    XP_005637793.1
540 aa
   Tcf7l2,  M.musculus
transcription factor 7 like 2, T cell specific, HMG box
    NP_001136394.1
598 aa
   Tcf7l2,  R.norvegicus
transcription factor 7-like 2 (T-cell specific, HMG-box)
    NP_001177981.1
598 aa
   TCF7L2,  G.gallus
transcription factor 7-like 2 (T-cell specific, HMG-box)
    NP_001193439.1
598 aa
   tcf7l2,  X.tropicalis
transcription factor 7-like 2 (T-cell specific, HMG-box)
    NP_001231922.1
483 aa
   tcf7l2,  D.rerio
transcription factor 7-like 2 (T-cell specific, HMG-box)
    NP_571334.1
477 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Diabetes mellitus, type 2, susceptibility to.



Publications
Articles associated with genes and sequences of this homology group.




Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
CTNNB1_binding (pfam08347)
  N-terminal CTNNB1 binding.
CTNNB1_binding (pfam08347)
  N-terminal CTNNB1 binding.
HMG-box (cl00082)
  High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Tcf7l2 includes H.sapiens TCF7L2 and R.norvegicus LOC679869.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (11 transcripts, 9 species)
Actinopterygii - bony fishes (10 transcripts, 6 species)
Ascidiacea - tunicates (3 transcripts, 3 species)
Aves - birds (3 transcripts, 1 species)
Amniota - vertebrates (2 transcripts, 1 species)
Amphibia - amphibians (2 transcripts, 2 species)
Cephalochordata - lancelets (1 transcript, 1 species)

Arthropoda
Insecta - insects (9 transcripts, 7 species)

Echinodermata
Echinoidea - sea urchins (2 transcripts, 2 species)

Mollusca
Gastropoda - gastropods (1 transcript, 1 species)

Cnidaria
Hydrozoa - hydrozoans (1 transcript, 1 species)

Annelida
Hirudinida - segmented worms (1 transcript, 1 species)

 

 

 

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