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HomoloGene:8720. Gene conserved in Eukaryota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   RABGEF1,  H.sapiens
RAB guanine nucleotide exchange factor (GEF) 1
    NP_001273990.1
505 aa
   RABGEF1,  P.troglodytes
RAB guanine nucleotide exchange factor (GEF) 1
    XP_003318527.1
505 aa
   LOC695887,  M.mulatta
rab5 GDP/GTP exchange factor-like
    XP_002803299.1
448 aa
   RABGEF1,  C.lupus
RAB guanine nucleotide exchange factor (GEF) 1
    XP_005620983.1
783 aa
   RABGEF1,  B.taurus
RAB guanine nucleotide exchange factor (GEF) 1
    NP_777016.1
492 aa
   Rabgef1,  M.musculus
RAB guanine nucleotide exchange factor (GEF) 1
    NP_001185988.1
491 aa
   Rabgef1,  R.norvegicus
RAB guanine nucleotide exchange factor (GEF) 1
    NP_001101803.1
502 aa
   rabgef1,  D.rerio
RAB guanine nucleotide exchange factor (GEF) 1
    NP_957137.1
502 aa
   Rabex-5,  D.melanogaster
Rabex-5
    NP_612093.1
696 aa
   AgaP_AGAP005551,  A.gambiae
AgaP_AGAP005551
    XP_315556.4
793 aa
   rabx-5,  C.elegans
rabx-5
    NP_499337.3
517 aa
   Os03g0842700,  O.sativa
Os03g0842700
    NP_001051858.1
218 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

RabGEF1, a negative regulator of Ras signalling, mast cell activation and skin inflammation.
Tam SY, et al. Novartis Found Symp 271, 115-24; discussion 124-30, 145-51 (2005).
Differential polyubiquitin recognition by tandem ubiquitin binding domains of Rabex-5.
Shin D, et al. Biochem Biophys Res Commun 423, 757-62 (2012).
[The expression and clinical significance of RABEX-5 and RAB5 in breast cancer].
Wang YJ, et al. Sichuan Da Xue Xue Bao Yi Xue Ban 42, 185-9 (2011).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
zf-A20 (pfam01754)
  A20-like zinc finger.
VPS9 (pfam02204)
  Vacuolar sorting protein 9 (VPS9) domain.
BTB (cl02518)
  BTB/POZ domain.
zf-A20 (cl11604)
  The A20 Zn-finger of bovine/human Rabex5/rabGEF1 is a Ubiquitin Binding Domain. The zinc finger mediates self-association in A20. These fingers also mediate IL-1-induced NF-kappa B activation.
VPS9 (cl19569)
  Vacuolar sorting protein 9 (VPS9) domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Rabgef1 includes H.sapiens RABGEF1 and R.norvegicus Rabgef1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (12 transcripts, 11 species)
Actinopterygii - bony fishes (12 transcripts, 8 species)
Ascidiacea - tunicates (2 transcripts, 2 species)
Aves - birds (2 transcripts, 2 species)
Amphibia - amphibians (2 transcripts, 2 species)

Arthropoda
Insecta - insects (5 transcripts, 5 species)
Arachnida - arachnids (2 transcripts, 1 species)

Cnidaria
Hydrozoa - hydrozoans (1 transcript, 1 species)
Anthozoa - anthozoans (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (2 transcripts, 2 species)

Mollusca
Gastropoda - gastropods (1 transcript, 1 species)

Platyhelminthes
Trematoda - flatworms (1 transcript, 1 species)

Annelida
Hirudinida - segmented worms (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (1 transcript, 1 species)

Streptophyta
Eudicotyledons - eudicots (5 transcripts, 4 species)
Liliopsida - monocots (2 transcripts, 2 species)

Oomycetes
Peronosporales - oomycetes (1 transcript, 1 species)

 

 

 

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