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HomoloGene:2589. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   PAX8,  H.sapiens
paired box 8
    NP_003457.1
450 aa
   PAX8,  P.troglodytes
paired box 8
    XP_003309249.2
389 aa
   PAX8,  M.mulatta
paired box 8
    XP_001093559.1
456 aa
   PAX8,  B.taurus
paired box 8
    XP_002691446.2
457 aa
   Pax8,  M.musculus
paired box 8
    NP_035170.1
457 aa
   Pax8,  R.norvegicus
paired box 8
    NP_112403.2
457 aa
   pax8,  X.tropicalis
paired box 8
    NP_001072769.2
466 aa
   pax8,  D.rerio
paired box gene 8
    XP_001339893.5
448 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Hypothyroidism, congenital, due to thyroid dysgenesis or hypoplasia.



Publications
Articles associated with genes and sequences of this homology group.

Pax8 has a critical role in epithelial cell survival and proliferation.
Di Palma T, et al. Cell Death Dis 4, e729 (2013).
Screening of PAX8 mutations in Chinese patients with congenital hypothyroidism.
Liu SG, et al. J Endocrinol Invest 35, 889-92 (2012).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Pax2_C (pfam12403)
  Paired-box protein 2 C terminal.
Pax2_C (pfam12403)
  Paired-box protein 2 C terminal.
PAX (cl19075)
  Paired Box domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Pax8 includes H.sapiens PAX8 and R.norvegicus Pax8.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (11 transcripts, 11 species)
Actinopterygii - bony fishes (2 transcripts, 2 species)
Amphibia - amphibians (2 transcripts, 2 species)

Arthropoda
Insecta - insects (2 transcripts, 2 species)
Arachnida - arachnids (1 transcript, 1 species)

Cnidaria
Anthozoa - anthozoans (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (1 transcript, 1 species)

 

 

 

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