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HomoloGene:830. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   TOP2A,  H.sapiens
topoisomerase (DNA) II alpha 170kDa
    NP_001058.2
1531 aa
   TOP2A,  P.troglodytes
topoisomerase (DNA) II alpha 170kDa
    XP_003315524.1
1500 aa
   TOP2A,  M.mulatta
DNA topoisomerase 2-alpha-like
    XP_002808175.1
1481 aa
   TOP2A,  C.lupus
topoisomerase (DNA) II alpha 170kDa
    XP_537646.2
1532 aa
   TOP2A,  B.taurus
topoisomerase (DNA) II alpha 170kDa
    XP_002696055.2
1530 aa
   Top2a,  M.musculus
topoisomerase (DNA) II alpha
    NP_035753.2
1528 aa
   Top2a,  R.norvegicus
topoisomerase (DNA) II alpha
    NP_071519.2
1526 aa
   TOP2A,  G.gallus
topoisomerase (DNA) II alpha 170kDa
    NP_990122.1
1553 aa
   topoii,  X.tropicalis
DNA topoisomerase 2-alpha
    XP_002942632.2
1698 aa
   top2a,  D.rerio
topoisomerase (DNA) II alpha
    NP_001003834.1
1574 aa
   Top2,  D.melanogaster
Topoisomerase 2
    NP_001260580.1
1447 aa
   AgaP_AGAP008917,  A.gambiae
AgaP_AGAP008917
    XP_319665.4
1427 aa
   top-2,  C.elegans
top-2
    NP_496536.1
1520 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

D.melanogaster
Top2 is an essential gene that encodes the large subunit of type II DNA topoisomerase, an enzyme believed to play an important role in the condensation, decondensation, and segregation of chromosomes. The enzyme is a major component of the nuclear matrix of Drosophila cells (Berrios, Osheroff and Fisher, 1985) and is distributed along polytene chromosomes paralleling the distribution of the DNA (Heller, Shelton, Dietrich, Elgin and Brutlag, 1986). It is believed to act by passing a DNA segment through a transient double-stranded break in another segment. (See FlyBase for complete description.)

H.sapiens
DNA topoisomerase II, resistance to inhibition of, by amsacrine.



Publications
Articles associated with genes and sequences of this homology group.

TOP2A RNA expression and recurrence in estrogen receptor-positive breast cancer.
Sparano JA, et al. Breast Cancer Res Treat 134, 751-7 (2012).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
DTHCT (pfam08070)
  DTHCT (NUC029) region.
PRK03577 (PRK03577)
  acid shock protein precursor; Provisional.
TOP4c (cd00187)
  DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes ...
DTHCT (pfam08070)
  DTHCT (NUC029) region.
HATPase_c (cl00075)
  Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins.
TOPRIM (cl00718)
  Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from ...
TopoII_MutL_Trans (cl02783)
  MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of type II DNA topoisomerases (Topo II) and DNA mismatch repair (MutL/MLH1/PMS2) proteins. This transducer domain is homologous to the second ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Top2a includes H.sapiens TOP2A and R.norvegicus Top2a.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (20 transcripts, 13 species)
Actinopterygii - bony fishes (14 transcripts, 8 species)
Ascidiacea - tunicates (5 transcripts, 2 species)
Amphibia - amphibians (5 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)
Aves - birds (1 transcript, 1 species)
Cephalochordata - lancelets (1 transcript, 1 species)

Arthropoda
Insecta - insects (8 transcripts, 7 species)
Arachnida - arachnids (4 transcripts, 2 species)
Branchiopoda - crustaceans (3 transcripts, 1 species)
Malacostraca - crustaceans (1 transcript, 1 species)
Maxillopoda - crustaceans (1 transcript, 1 species)

Cnidaria
Anthozoa - anthozoans (4 transcripts, 1 species)
Hydrozoa - hydrozoans (2 transcripts, 2 species)

Nematoda
Chromadorea - nematodes (6 transcripts, 1 species)

Annelida
Polychaeta - segmented worms (2 transcripts, 1 species)
Hirudinida - segmented worms (1 transcript, 1 species)

Mollusca
Gastropoda - gastropods (2 transcripts, 2 species)

Echinodermata
Echinoidea - sea urchins (2 transcripts, 1 species)

Platyhelminthes
Trematoda - flatworms (1 transcript, 1 species)

Streptophyta
Eudicotyledons - eudicots (20 transcripts, 13 species)
Liliopsida - monocots (15 transcripts, 9 species)

Ascomycota
Sordariomycetes - ascomycetes (1 transcript, 1 species)
Eurotiomycetes - ascomycetes (1 transcript, 1 species)
Pezizomycetes - ascomycetes (1 transcript, 1 species)

Basidiomycota
Heterobasidiomycetes - basidiomycetes (1 transcript, 1 species)

Bacillariophyta
Bacillariophyceae - diatoms (2 transcripts, 1 species)

Oomycetes
Peronosporales - oomycetes (2 transcripts, 1 species)

Ciliophora
Oligohymenophorea - ciliates (3 transcripts, 2 species)

Apicomplexa
Coccidia - apicomplexans (1 transcript, 1 species)

Dictyosteliida
Dictyostelium - cellular slime molds (1 transcript, 1 species)

 

 

 

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