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HomoloGene:219. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   MYO7A,  H.sapiens
myosin VIIA
    NP_000251.3
2215 aa
   MYO7A,  P.troglodytes
myosin VIIA
    XP_003313297.2
2178 aa
   MYO7A,  M.mulatta
myosin VIIA
    XP_001087868.2
2232 aa
   MYO7A,  C.lupus
myosin VIIA
    XP_005633514.1
2215 aa
   MYO7A,  B.taurus
myosin VIIA
    XP_005216396.1
2177 aa
   Myo7a,  M.musculus
myosin VIIA
    NP_001243010.1
2215 aa
   Myo7a,  R.norvegicus
myosin VIIA
    NP_703203.1
2177 aa
   MYO7A,  G.gallus
myosin VIIA
    XP_004938998.1
2234 aa
   myo7a,  X.tropicalis
myosin VIIA
    XP_004912319.1
2212 aa
   myo7aa,  D.rerio
myosin VIIAa
    NP_694515.1
2179 aa
   ck,  D.melanogaster
crinkled
    NP_523571.1
2167 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

D.melanogaster
Recessive lethal or semi-lethal. ck embryos exhibit denticles thickset and forked; hairs basally fused; sensory hairs blunt (Nusslein-Volhard, Wieschaus, and Kluding, 1984). Hemizygous survivors, or survivors among heteroallelic combinations that partially complement for viability, have stubbly chaetae, multiple trichomes, and feathery aristae (Gubb, Shelton, Roote, McGill and Ashburner, 1984). Variable expression of a wavy, crinkled wing phenotype. Cell viable in clones of adult epidermis; bristle and hair phenotypes autonomous; useful as a cell marker in 2L for clonal analysis (Struhl)..

H.sapiens
Usher syndrome, type 1B.
Deafness, autosomal recessive 2, neurosensory.
Deafness, autosomal dominant 11, neurosensory.



Publications
Articles associated with genes and sequences of this homology group.

Retinal disease course in Usher syndrome 1B due to MYO7A mutations.
Jacobson SG, et al. Invest Ophthalmol Vis Sci 52, 7924-36 (2011).
Functional characterization of the human myosin-7a motor domain.
Heissler SM & Manstein DJ. Cell Mol Life Sci 69, 299-311 (2012).
Cargo binding activates myosin VIIA motor function in cells.
Sakai T, et al. Proc Natl Acad Sci U S A 108, 7028-33 (2011).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
YscO (pfam07321)
  Type III secretion protein YscO.
IQ (pfam00612)
  IQ calmodulin-binding motif.
IQ (cl15479)
  IQ calmodulin-binding motif.
B41 (smart00295)
  Band 4.1 homologues.
FERM_M (pfam00373)
  FERM central domain.
MyTH4 (pfam00784)
  MyTH4 domain.
FERM_N (pfam09379)
  FERM N-terminal domain.
MyTH4 (cl02480)
  MyTH4 domain.
SH3 (cl17036)
  Src Homology 3 domain superfamily.
FERM_M (pfam00373)
  FERM central domain.
DUF1682 (pfam07946)
  Protein of unknown function (DUF1682).
FERM_N (pfam09379)
  FERM N-terminal domain.
PGBA_C (pfam15437)
  Plasminogen-binding protein pgbA C-terminal.
Motor_domain (cl00286)
  Myosin and Kinesin motor domain. These ATPases belong to the P-loop NTPase family and provide the driving force in myosin and kinesin mediated processes.
MyTH4 (cl02480)
  MyTH4 domain.
IQ (cl15479)
  Calmodulin-binding motif.
SH3 (cl17036)
  Src Homology 3 domain superfamily.
PH-like (cl17171)
  Pleckstrin homology-like domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Myo7a includes H.sapiens MYO7A and R.norvegicus Myo7a.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Actinopterygii - bony fishes (19 transcripts, 7 species)
Mammalia - mammals (11 transcripts, 7 species)
Ascidiacea - tunicates (3 transcripts, 2 species)
Cephalochordata - lancelets (1 transcript, 1 species)
Amphibia - amphibians (1 transcript, 1 species)

Arthropoda
Insecta - insects (15 transcripts, 8 species)
Arachnida - arachnids (2 transcripts, 1 species)
Branchiopoda - crustaceans (1 transcript, 1 species)
Maxillopoda - crustaceans (1 transcript, 1 species)

Annelida
Polychaeta - segmented worms (2 transcripts, 1 species)
Hirudinida - segmented worms (2 transcripts, 1 species)

Echinodermata
Echinoidea - sea urchins (3 transcripts, 2 species)

Cnidaria
Hydrozoa - hydrozoans (1 transcript, 1 species)
Anthozoa - anthozoans (1 transcript, 1 species)

Mollusca
Gastropoda - gastropods (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (1 transcript, 1 species)

Porifera
Demospongiae - sponges (1 transcript, 1 species)

Platyhelminthes
Turbellaria - flatworms (1 transcript, 1 species)

Streptophyta
Eudicotyledons - eudicots (11 transcripts, 8 species)
Bryopsida - mosses (2 transcripts, 1 species)
Liliopsida - monocots (1 transcript, 1 species)

Chlorophyta
Chlorophyceae - green algae (1 transcript, 1 species)

Oomycetes
Peronosporales - oomycetes (2 transcripts, 1 species)

Apicomplexa
Coccidia - apicomplexans (1 transcript, 1 species)

Codonosigidae
Monosiga - choanoflagellates (1 transcript, 1 species)

 

 

 

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