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HomoloGene:41065. Gene conserved in Bilateria Download , Links
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

   NOX4,  H.sapiens
NADPH oxidase 4
578 aa
   NOX4,  P.troglodytes
NADPH oxidase 4
578 aa
   NOX4,  M.mulatta
NADPH oxidase 4
578 aa
   NOX4,  C.lupus
NADPH oxidase 4
528 aa
   NOX4,  B.taurus
NADPH oxidase 4
578 aa
   Nox4,  M.musculus
NADPH oxidase 4
578 aa
   Nox4,  R.norvegicus
NADPH oxidase 4
578 aa
   NOX4,  G.gallus
NADPH oxidase 4
541 aa
   nox4,  X.tropicalis
NADPH oxidase 4
583 aa
   AgaP_AGAP003772,  A.gambiae
561 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Articles associated with genes and sequences of this homology group.

Bone disorders: targeting NOX4 knocks down osteoporosis.
Harrison C. Nat Rev Drug Discov 12, 904 (2013).
Nox as a target for diabetic complications.
Gorin Y & Block K. Clin Sci (Lond) 125, 361-82 (2013).

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Ferric_reduct (pfam01794)
  Ferric reductase like transmembrane component.
Ferric_reduct (cl01043)
  This family includes a common region in the transmembrane proteins mammalian cytochrome B-245 heavy chain (gp91-phox), ferric reductase transmembrane component in yeast and respiratory burst oxidase from mouse-ear cress. This may be a family of flavocytochromes capable of moving electrons across the plasma membrane. The Frp1 protein from S. pombe is a ferric reductase component and is required for cell surface ferric reductase activity, mutants in frp1 are deficient in ferric iron uptake. Cytochrome B-245 heavy chain is a FAD-dependent dehydrogenase it is also has electron transferase activity which reduces molecular oxygen to superoxide anion, a precursor in the production of microbicidal oxidants. Mutations in the sequence of cytochrome B-245 heavy chain (gp91-phox) lead to the X-linked chronic granulomatous disease. The bacteriocidal ability of phagocytic cells is reduced and is characterized by the absence of a functional plasma membrane associated NADPH oxidase. The chronic granulomatous disease gene codes for the beta chain of cytochrome B-245 and cytochrome B-245 is missing from patients with the disease.
FNR_like (cl06868)
  Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport ...

Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Nox4 includes H.sapiens NOX4 and R.norvegicus Nox4.

Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Mammalia - mammals (15 transcripts, 10 species)
Amniota - vertebrates (1 transcript, 1 species)
Actinopterygii - bony fishes (1 transcript, 1 species)
Aves - birds (1 transcript, 1 species)

Hydrozoa - hydrozoans (1 transcript, 1 species)




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