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HomoloGene:55616. Gene conserved in Eukaryota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   CTSD,  H.sapiens
cathepsin D
    NP_001900.1
412 aa
   CTSD,  M.mulatta
cathepsin D
    XP_001091601.1
412 aa
   CTSD,  C.lupus
cathepsin D
    NP_001020792.1
410 aa
   CTSD,  B.taurus
cathepsin D
    NP_001159993.1
410 aa
   Ctsd,  M.musculus
cathepsin D
    NP_034113.1
410 aa
   Ctsd,  R.norvegicus
cathepsin D
    NP_599161.2
407 aa
   CTSD,  G.gallus
cathepsin D
    NP_990508.1
398 aa
   ctsd,  X.tropicalis
cathepsin D
    NP_988964.1
398 aa
   LOC613063,  X.tropicalis
cathepsin D-like
    NP_001136375.1
399 aa
   LOC101735147,  X.tropicalis
cathepsin D-like
    XP_004914286.1
354 aa
   LOC100489529,  X.tropicalis
cathepsin D-like
    XP_002938948.2
336 aa
   ctsd,  D.rerio
cathepsin D
    NP_571785.1
399 aa
   cathD,  D.melanogaster
cathD
    NP_652013.1
392 aa
   AgaP_AGAP003277,  A.gambiae
AgaP_AGAP003277
    XP_307784.1
389 aa
   asp-4,  C.elegans
asp-4
    NP_510191.1
444 aa
   PEP4,  S.cerevisiae
PEP4
    NP_015171.1
405 aa
   KLLA0D05929g,  K.lactis
KLLA0D05929g
    XP_453326.1
409 aa
   MGG_00922,  M.oryzae
MGG_00922
    XP_003718037.1
395 aa
   NCU02273,  N.crassa
NCU02273
    XP_959917.1
396 aa
   APA1,  A.thaliana
APA1
    NP_172655.1
506 aa
   AT1G62290,  A.thaliana
AT1G62290
    NP_001031219.1
513 aa
   Os05g0567100,  O.sativa
Os05g0567100
    NP_001056348.1
509 aa
   Os01g0663400,  O.sativa
Os01g0663400
    NP_001043786.1
522 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Ceroid lipofuscinosis, neuronal, 10.



Publications
Articles associated with genes and sequences of this homology group.

Overexpression of cathepsin D in malignant melanoma.
Zhu L, et al. Fukuoka Igaku Zasshi 104, 370-5 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
SapB_2 (pfam03489)
  Saposin-like type B, region 2.
A1_Propeptide (pfam07966)
  A1 Propeptide.
SapB_1 (pfam05184)
  Saposin-like type B, region 1.
pepsin_retropepsin_like (cl11403)
  Cellular and retroviral pepsin-like aspartate proteases.
SapB_2 (pfam03489)
  Saposin-like type B, region 2.
SapB_1 (pfam05184)
  Saposin-like type B, region 1.
pepsin_retropepsin_like (cl11403)
  Cellular and retroviral pepsin-like aspartate proteases.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Ctsd includes H.sapiens CTSD and R.norvegicus Ctsd.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (25 transcripts, 15 species)
Actinopterygii - bony fishes (15 transcripts, 10 species)
Ascidiacea - tunicates (6 transcripts, 3 species)
Amphibia - amphibians (6 transcripts, 2 species)
Cephalochordata - lancelets (4 transcripts, 1 species)
Aves - birds (2 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)
Hyperoartia - vertebrates (1 transcript, 1 species)

Arthropoda
Insecta - insects (23 transcripts, 12 species)
Arachnida - arachnids (4 transcripts, 2 species)
Branchiopoda - crustaceans (3 transcripts, 1 species)
Malacostraca - crustaceans (3 transcripts, 1 species)
Maxillopoda - crustaceans (3 transcripts, 1 species)

Platyhelminthes
Trematoda - flatworms (6 transcripts, 2 species)
Turbellaria - flatworms (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (4 transcripts, 2 species)

Mollusca
Gastropoda - gastropods (3 transcripts, 2 species)

Cnidaria
Hydrozoa - hydrozoans (2 transcripts, 2 species)
Anthozoa - anthozoans (1 transcript, 1 species)

Porifera
Demospongiae - sponges (2 transcripts, 1 species)

Annelida
Polychaeta - segmented worms (1 transcript, 1 species)
Hirudinida - segmented worms (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (2 transcripts, 2 species)

Streptophyta
Eudicotyledons - eudicots (42 transcripts, 19 species)
Liliopsida - monocots (13 transcripts, 5 species)
Coniferopsida - conifers (10 transcripts, 3 species)
Isoetopsida - club-mosses (1 transcript, 1 species)

Chlorophyta
Chlorophyceae - green algae (2 transcripts, 1 species)

Ascomycota
Sordariomycetes - ascomycetes (6 transcripts, 3 species)
Eurotiomycetes - ascomycetes (1 transcript, 1 species)
Pezizomycetes - ascomycetes (1 transcript, 1 species)

Basidiomycota
Heterobasidiomycetes - basidiomycetes (2 transcripts, 1 species)

Oomycetes
Pythiales - oomycetes (2 transcripts, 1 species)
Peronosporales - oomycetes (1 transcript, 1 species)

Bacillariophyta
Bacillariophyceae - diatoms (2 transcripts, 1 species)

Ciliophora
Oligohymenophorea - ciliates (2 transcripts, 1 species)

Apicomplexa
Coccidia - apicomplexans (1 transcript, 1 species)

Dictyosteliida
Dictyostelium - cellular slime molds (1 transcript, 1 species)

Codonosigidae
Monosiga - choanoflagellates (1 transcript, 1 species)

 

 

 

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