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HomoloGene:76480. Gene conserved in Diptera Download , Links
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

   Ace,  D.melanogaster
Acetylcholine esterase
649 aa
   AgaP_AGAP000466,  A.gambiae
645 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Phenotypic information for the genes in this entry imported from model organism databases.

Loss of function alleles are recessive lethal dying at end of embryonic stage; then ultrastructural observations of CNS in such mutants suggest neural-degenerative defects (FBrf0047827). Ace-minus tissues survive in mosaics unless enzyme absent from posterior midbrain; surviving mosaics have defective visual physiology, optomotor behavior or courtship, depending on location of mutant clone. Such clones associated with defective morphology or neuropil of various ganglia in central nervous system (FBrf0035219). (See FlyBase for complete description.)

Articles associated with genes and sequences of this homology group.

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
COesterase (pfam00135)
  Carboxylesterase family.
Aes (COG0657)
  Esterase/lipase [Lipid metabolism].

Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Insecta - insects (9 transcripts, 8 species)
Arachnida - arachnids (1 transcript, 1 species)




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