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HomoloGene:9675. Gene conserved in Eukaryota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   OGT,  H.sapiens
O-linked N-acetylglucosamine (GlcNAc) transferase
    NP_858058.1
1046 aa
   OGT,  P.troglodytes
O-linked N-acetylglucosamine (GlcNAc) transferase
    XP_521123.4
1022 aa
   OGT,  C.lupus
O-linked N-acetylglucosamine (GlcNAc) transferase
    XP_849392.1
1046 aa
   OGT,  B.taurus
O-linked N-acetylglucosamine (GlcNAc) transferase
    NP_001091539.1
1036 aa
   Ogt,  M.musculus
O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)
    NP_631883.2
1046 aa
   Ogt,  R.norvegicus
O-linked N-acetylglucosamine (GlcNAc) transferase
    NP_058803.2
1036 aa
   OGT,  G.gallus
O-linked N-acetylglucosamine (GlcNAc) transferase
    XP_001232519.1
1035 aa
   ogt,  X.tropicalis
O-linked N-acetylglucosamine (GlcNAc) transferase
    NP_001019747.1
1035 aa
   ogt.1,  D.rerio
O-linked N-acetylglucosamine (GlcNAc) transferase, tandem duplicate 1
    NP_001018116.1
1046 aa
   sxc,  D.melanogaster
super sex combs
    NP_724407.1
1059 aa
   AgaP_AGAP006254,  A.gambiae
AgaP_AGAP006254
    XP_316319.4
1120 aa
   ogt-1,  C.elegans
ogt-1
    NP_001040860.1
1151 aa
   SEC,  A.thaliana
SEC
    NP_187074.1
977 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

Cardiomyocyte Ogt is essential for postnatal viability.
Watson LJ, et al. Am J Physiol Heart Circ Physiol 306, H142-53 (2014).
O-GlcNAc cycling: a link between metabolism and chronic disease.
Bond MR & Hanover JA. Annu Rev Nutr 33, 205-29 (2013).
Structural snapshots of the reaction coordinate for O-GlcNAc transferase.
Lazarus MB, et al. Nat Chem Biol 8, 966-8 (2012).
A role for O-GlcNAcylation in setting circadian clock speed.
Kim EY, et al. Genes Dev 26, 490-502 (2012).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
TPR_12 (pfam13424)
  Tetratricopeptide repeat.
Glyco_transf_41 (pfam13844)
  Glycosyl transferase family 41.
TPR_11 (pfam13414)
  TPR repeat.
NrfG (COG0457)
  FOG: TPR repeat [General function prediction only].
TPR (cd00189)
  Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]-X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, ...
TPR_11 (pfam13414)
  TPR repeat.
TPR_12 (pfam13424)
  Tetratricopeptide repeat.
TPR_1 (cl02429)
  Repeats present in 4 or more copies in proteins. Contain a minimum of 34 amino acids each and self-associate via a "knobs and holes" mechanism.
Glycos_transf_1 (cl19138)
  Glycosyl transferases group 1.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Ogt includes H.sapiens OGT and R.norvegicus Ogt.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (21 transcripts, 15 species)
Actinopterygii - bony fishes (19 transcripts, 10 species)
Aves - birds (4 transcripts, 3 species)
Amphibia - amphibians (4 transcripts, 2 species)
Ascidiacea - tunicates (3 transcripts, 3 species)
Amniota - vertebrates (1 transcript, 1 species)
Cephalochordata - lancelets (1 transcript, 1 species)
Hyperoartia - vertebrates (1 transcript, 1 species)

Arthropoda
Insecta - insects (16 transcripts, 11 species)
Arachnida - arachnids (2 transcripts, 2 species)
Branchiopoda - crustaceans (1 transcript, 1 species)
Malacostraca - crustaceans (1 transcript, 1 species)
Maxillopoda - crustaceans (1 transcript, 1 species)

Platyhelminthes
Trematoda - flatworms (2 transcripts, 2 species)
Turbellaria - flatworms (2 transcripts, 1 species)

Annelida
Polychaeta - segmented worms (2 transcripts, 1 species)
Hirudinida - segmented worms (2 transcripts, 1 species)

Mollusca
Gastropoda - gastropods (3 transcripts, 2 species)

Cnidaria
Hydrozoa - hydrozoans (2 transcripts, 1 species)
Anthozoa - anthozoans (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (2 transcripts, 2 species)

Echinodermata
Echinoidea - sea urchins (2 transcripts, 2 species)

Porifera
Demospongiae - sponges (1 transcript, 1 species)

Streptophyta
Eudicotyledons - eudicots (55 transcripts, 34 species)
Liliopsida - monocots (13 transcripts, 9 species)
Coniferopsida - conifers (7 transcripts, 3 species)
Bryopsida - mosses (2 transcripts, 1 species)
Isoetopsida - club-mosses (2 transcripts, 1 species)

Ascomycota
Sordariomycetes - ascomycetes (1 transcript, 1 species)

Oomycetes
Peronosporales - oomycetes (1 transcript, 1 species)

Codonosigidae
Monosiga - choanoflagellates (1 transcript, 1 species)

 

 

 

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