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HomoloGene:3961. Gene conserved in Bilateria Download , Links
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

   VAV1,  H.sapiens
vav 1 guanine nucleotide exchange factor
845 aa
   VAV1,  P.troglodytes
vav 1 guanine nucleotide exchange factor
789 aa
   VAV1,  C.lupus
vav 1 guanine nucleotide exchange factor
844 aa
   VAV1,  B.taurus
vav 1 guanine nucleotide exchange factor
844 aa
   Vav1,  M.musculus
vav 1 oncogene
845 aa
   Vav1,  R.norvegicus
vav 1 guanine nucleotide exchange factor
843 aa
   LOC100497964,  X.tropicalis
proto-oncogene vav-like
844 aa
   vav,  D.melanogaster
793 aa
   AgaP_AGAP010292,  A.gambiae
762 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Articles associated with genes and sequences of this homology group.

Vav Guanine nucleotide exchange factors regulate atherosclerotic lesion development in mice.
Rahaman SO, et al. Arterioscler Thromb Vasc Biol 33, 2053-7 (2013).

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
PH-like (cl00273)
  Pleckstrin homology-like domain.
SH3 (cl17036)
  Src Homology 3 domain superfamily.
CH (cl00030)
  Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
C1 (cl00040)
  Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
RhoGEF (cl02571)
  Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
SH2 (cl15255)
  Src homology 2 (SH2) domain.
SH3 (cl17036)
  Src Homology 3 domain superfamily.
PH-like (cl17171)
  Pleckstrin homology-like domain.

Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Vav1 includes H.sapiens VAV1 and R.norvegicus Vav1.

Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Mammalia - mammals (16 transcripts, 11 species)
Actinopterygii - bony fishes (6 transcripts, 6 species)
Amphibia - amphibians (3 transcripts, 2 species)

Insecta - insects (9 transcripts, 5 species)
Branchiopoda - crustaceans (1 transcript, 1 species)




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