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HomoloGene:123817. Gene conserved in Eukaryota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   EIF4E,  H.sapiens
eukaryotic translation initiation factor 4E
    NP_001124151.1
248 aa
   EIF4E,  P.troglodytes
eukaryotic translation initiation factor 4E
    NP_001233399.1
217 aa
   EIF4E,  M.mulatta
eukaryotic translation initiation factor 4E
    XP_001104976.1
217 aa
   EIF4E,  C.lupus
eukaryotic translation initiation factor 4E
    XP_005639275.1
217 aa
   EIF4E,  B.taurus
eukaryotic translation initiation factor 4E
    NP_776735.2
217 aa
   Eif4e,  M.musculus
eukaryotic translation initiation factor 4E
    NP_031943.3
217 aa
   Eif4e,  R.norvegicus
eukaryotic translation initiation factor 4E
    NP_446426.1
217 aa
   EIF4E,  G.gallus
eukaryotic translation initiation factor 4E
    XP_420655.4
233 aa
   eif4e,  X.tropicalis
eukaryotic translation initiation factor 4E
    NP_001015909.1
214 aa
   eif4eb,  D.rerio
eukaryotic translation initiation factor 4eb
    NP_001007778.1
216 aa
   eif4ea,  D.rerio
eukaryotic translation initiation factor 4ea
    NP_571808.1
215 aa
   eIF-4E,  D.melanogaster
Eukaryotic initiation factor 4E
    NP_729485.1
259 aa
   eIF4E-4,  D.melanogaster
eIF4E-4
    NP_648052.1
229 aa
   eIF4E-7,  D.melanogaster
eIF4E-7
    NP_726718.1
429 aa
   eIF4E-5,  D.melanogaster
eIF4E-5
    NP_648160.2
232 aa
   eIF4E-3,  D.melanogaster
eukaryotic translation initiation factor 4E-3
    NP_648194.1
244 aa
   AgaP_AGAP007172,  A.gambiae
AgaP_AGAP007172
    XP_001688027.1
254 aa
   ife-3,  C.elegans
ife-3
    NP_503124.1
248 aa
   EIF4E,  A.thaliana
EIF4E
    NP_193538.1
235 aa
   Os01g0970400,  O.sativa
Os01g0970400
    NP_001045525.1
227 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
???.



Publications
Articles associated with genes and sequences of this homology group.

eIF4E-bound mRNPs are substrates for nonsense-mediated mRNA decay in mammalian cells.
Rufener SC & Mühlemann O. Nat Struct Mol Biol 20, 710-7 (2013).
Nonsense-mediated mRNA decay occurs during eIF4F-dependent translation in human cells.
Durand S & Lykke-Andersen J. Nat Struct Mol Biol 20, 702-9 (2013).
The oncogene eIF4E: using biochemical insights to target cancer.
Carroll M & Borden KL. J Interferon Cytokine Res 33, 227-38 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
IF4E (pfam01652)
  Eukaryotic initiation factor 4E.
IF4E (cl02106)
  Eukaryotic initiation factor 4E.
ZipA (cl12038)
  ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Eif4e includes H.sapiens EIF4E and R.norvegicus Eif4e.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (23 transcripts, 16 species)
Actinopterygii - bony fishes (10 transcripts, 8 species)
Amphibia - amphibians (5 transcripts, 2 species)
Ascidiacea - tunicates (4 transcripts, 3 species)
Aves - birds (3 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)
Cephalochordata - lancelets (1 transcript, 1 species)
Hyperoartia - vertebrates (1 transcript, 1 species)

Arthropoda
Insecta - insects (21 transcripts, 10 species)
Arachnida - arachnids (3 transcripts, 2 species)
Maxillopoda - crustaceans (1 transcript, 1 species)

Platyhelminthes
Trematoda - flatworms (3 transcripts, 2 species)

Cnidaria
Hydrozoa - hydrozoans (1 transcript, 1 species)
Anthozoa - anthozoans (1 transcript, 1 species)

Mollusca
Gastropoda - gastropods (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (1 transcript, 1 species)

Streptophyta
Eudicotyledons - eudicots (51 transcripts, 33 species)
Liliopsida - monocots (14 transcripts, 7 species)
Bryopsida - mosses (4 transcripts, 1 species)
Coniferopsida - conifers (3 transcripts, 3 species)
Isoetopsida - club-mosses (2 transcripts, 1 species)

Chlorophyta
Chlorophyceae - green algae (3 transcripts, 2 species)

 

 

 

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