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HomoloGene:22494. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   PAX3,  H.sapiens
paired box 3
    NP_001120838.1
483 aa
   PAX3,  P.troglodytes
paired box 3
    XP_001165390.2
484 aa
   PAX3,  M.mulatta
paired box 3
    XP_001107687.2
484 aa
   PAX3,  C.lupus
paired box 3
    XP_005640772.1
514 aa
   PAX3,  B.taurus
paired box 3
    NP_001193747.1
484 aa
   Pax3,  M.musculus
paired box 3
    NP_001152992.1
484 aa
   Pax3,  R.norvegicus
paired box 3
    NP_446162.1
484 aa
   PAX3,  G.gallus
paired box 3
    NP_989600.1
484 aa
   pax3,  X.tropicalis
paired box 3
    NP_001006776.2
461 aa
   pax3a,  D.rerio
paired box gene 3a
    NP_571352.1
509 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Craniofacial-deafness-hand syndrome.
Waardenburg syndrome, type III.
Waardenburg syndrome, type I.
Rhabdomyosarcoma, alveolar.



Publications
Articles associated with genes and sequences of this homology group.

Genetic analysis of PAX3 for diagnosis of Waardenburg syndrome type I.
Matsunaga T, et al. Acta Otolaryngol 133, 345-51 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Pax7 (pfam12360)
  Paired box protein 7.
homeodomain (cl00084)
  Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
PAX (cl19075)
  Paired Box domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Pax3 includes H.sapiens PAX3 and R.norvegicus Pax3.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (9 transcripts, 7 species)
Actinopterygii - bony fishes (9 transcripts, 5 species)
Amphibia - amphibians (3 transcripts, 2 species)
Aves - birds (1 transcript, 1 species)

Arthropoda
Insecta - insects (5 transcripts, 5 species)

Cnidaria
Anthozoa - anthozoans (2 transcripts, 1 species)

Mollusca
Gastropoda - gastropods (1 transcript, 1 species)

Annelida
Hirudinida - segmented worms (1 transcript, 1 species)

 

 

 

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