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HomoloGene:2736. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   CASK,  H.sapiens
calcium/calmodulin-dependent serine protein kinase (MAGUK family)
    NP_003679.2
921 aa
   CASK,  P.troglodytes
calcium/calmodulin-dependent serine protein kinase (MAGUK family)
    XP_003317477.2
921 aa
   CASK,  M.mulatta
calcium/calmodulin-dependent serine protein kinase (MAGUK family)
    XP_001095837.2
921 aa
   CASK,  C.lupus
calcium/calmodulin-dependent serine protein kinase (MAGUK family)
    XP_005641318.1
926 aa
   CASK,  B.taurus
calcium/calmodulin-dependent serine protein kinase (MAGUK family)
    NP_001095951.1
908 aa
   Cask,  M.musculus
calcium/calmodulin-dependent serine protein kinase (MAGUK family)
    NP_001271432.1
926 aa
   Cask,  R.norvegicus
calcium/calmodulin-dependent serine protein kinase (MAGUK family)
    NP_071520.1
909 aa
   CASK,  G.gallus
calcium/calmodulin-dependent serine protein kinase (MAGUK family)
    XP_416769.3
859 aa
   cask,  X.tropicalis
calcium/calmodulin-dependent serine protein kinase (MAGUK family)
    NP_001016204.1
920 aa
   caska,  D.rerio
calcium/calmodulin-dependent serine protein kinase a
    NP_694420.1
920 aa
   CASK,  D.melanogaster
CASK ortholog
    NP_001262811.1
929 aa
   AgaP_AGAP001683,  A.gambiae
AgaP_AGAP001683
    XP_001238476.3
918 aa
   lin-2,  C.elegans
lin-2
    NP_001024587.1
961 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Mental retardation and microcephaly with pontine and cerebellar hypoplasia.



Publications
Articles associated with genes and sequences of this homology group.

CASK-Related Disorders
Moog U, et al. (1993).
Pre and postsynaptic roles for Drosophila CASK.
Chen K & Featherstone DE. Mol Cell Neurosci 48, 171-82 (2011).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Guanylate_kin (pfam00625)
  Guanylate kinase.
S_TKc (smart00220)
  Serine/Threonine protein kinases, catalytic domain.
L27 (pfam02828)
  L27 domain.
AATF-Che1 (pfam13339)
  Apoptosis antagonizing transcription factor.
Guanylate_kin (pfam00625)
  Guanylate kinase.
PDZ (cl00117)
  PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...
L27 (cl02672)
  L27 domain.
SH3 (cl17036)
  Src Homology 3 domain superfamily.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Cask includes H.sapiens CASK and R.norvegicus Cask.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Actinopterygii - bony fishes (27 transcripts, 7 species)
Mammalia - mammals (11 transcripts, 11 species)
Ascidiacea - tunicates (3 transcripts, 3 species)
Amniota - vertebrates (2 transcripts, 1 species)
Aves - birds (2 transcripts, 2 species)
Amphibia - amphibians (2 transcripts, 2 species)
Cephalochordata - lancelets (1 transcript, 1 species)

Arthropoda
Insecta - insects (10 transcripts, 7 species)

Nematoda
Chromadorea - nematodes (2 transcripts, 2 species)

Platyhelminthes
Trematoda - flatworms (1 transcript, 1 species)
Turbellaria - flatworms (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (2 transcripts, 2 species)

Mollusca
Gastropoda - gastropods (1 transcript, 1 species)

Annelida
Hirudinida - segmented worms (1 transcript, 1 species)

 

 

 

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