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HomoloGene:27831. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   TPH2,  H.sapiens
tryptophan hydroxylase 2
    NP_775489.2
490 aa
   TPH2,  P.troglodytes
tryptophan hydroxylase 2
    XP_522470.2
490 aa
   TPH2,  M.mulatta
tryptophan hydroxylase 2
    NP_001035035.1
490 aa
   TPH2,  C.lupus
tryptophan hydroxylase 2
    NP_001184049.1
491 aa
   Tph2,  M.musculus
tryptophan hydroxylase 2
    NP_775567.2
488 aa
   Tph2,  R.norvegicus
tryptophan hydroxylase 2
    NP_776211.1
485 aa
   TPH2,  G.gallus
tryptophan hydroxylase 2
    NP_001001301.1
489 aa
   tph2,  X.tropicalis
tryptophan hydroxylase 2
    XP_004913008.1
485 aa
   tph2,  D.rerio
tryptophan hydroxylase 2 (tryptophan 5-monooxygenase)
    NP_999960.1
473 aa
   tph-1,  C.elegans
tph-1
    NP_495584.4
532 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Unipolar depression, susceptibility to.



Publications
Articles associated with genes and sequences of this homology group.

Development × environment interactions control tph2 mRNA expression.
Lukkes JL, et al. Neuroscience 237, 139-50 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Trp_5_monoox (TIGR01270)
  tryptophan 5-monooxygenase, tetrameric.
ACT (cl09141)
  ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme.
arom_aa_hydroxylase (cl01244)
  Biopterin-dependent aromatic amino acid hydroxylase; a family of non-heme, iron(II)-dependent enzymes that includes prokaryotic and eukaryotic phenylalanine-4-hydroxylase (PheOH), eukaryotic tyrosine hydroxylase (TyrOH) and eukaryotic tryptophan ...
ACT (cl09141)
  ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Tph2 includes H.sapiens TPH2 and R.norvegicus Tph2.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (9 transcripts, 8 species)
Actinopterygii - bony fishes (7 transcripts, 6 species)
Aves - birds (2 transcripts, 2 species)

Platyhelminthes
Turbellaria - flatworms (1 transcript, 1 species)

 

 

 

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