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HomoloGene:37650. Gene conserved in Eukaryota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

PKM,  H.sapiens
pyruvate kinase, muscle
NP_001193725.1
605 aa
PKM,  P.troglodytes
pyruvate kinase, muscle
XP_003314790.1
605 aa
PKM,  M.mulatta
pyruvate kinase, muscle
XP_001099473.2
531 aa
PKM,  C.lupus
pyruvate kinase, muscle
XP_005638614.1
591 aa
PKM,  B.taurus
pyruvate kinase, muscle
NP_001192656.1
531 aa
Pkm,  M.musculus
pyruvate kinase, muscle
NP_035229.2
531 aa
Pkm,  R.norvegicus
pyruvate kinase, muscle
NP_445749.1
531 aa
PKM2,  G.gallus
pyruvate kinase, muscle
NP_990800.1
530 aa
pkm,  X.tropicalis
pyruvate kinase, muscle
NP_001072532.1
527 aa
pkma,  D.rerio
pyruvate kinase, muscle, a
NP_955365.1
532 aa
PyK,  D.melanogaster
Pyruvate kinase
NP_524448.3
533 aa
AgaP_AGAP004596,  A.gambiae
AgaP_AGAP004596
XP_315228.5
518 aa
pyk-1,  C.elegans
pyk-1
NP_001251014.1
913 aa
pyk-2,  C.elegans
pyk-2
NP_001255515.1
515 aa
CDC19,  S.cerevisiae
CDC19
NP_009362.1
500 aa
KLLA0F23397g,  K.lactis
KLLA0F23397g
XP_456122.1
501 aa
AGOS_ADR368W,  E.gossypii
AGOS_ADR368W
NP_984464.1
501 aa
pyk1,  S.pombe
pyk1
NP_594346.1
509 aa
MGG_08063,  M.oryzae
MGG_08063
XP_003715015.1
528 aa
NCU06075,  N.crassa
NCU06075
XP_959838.1
527 aa
AT5G63680,  A.thaliana
AT5G63680
NP_201173.1
510 aa
AT5G08570,  A.thaliana
AT5G08570
NP_196474.1
510 aa
Os04g0677500,  O.sativa
Os04g0677500
NP_001054265.1
511 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

D.melanogaster
Structural gene for the glycolytic enzyme pyruvate kinase (PYK = ATP: pyruvate phosphotransferase). Enzyme activity low in larvae and pupae, but it increases in young adults, becoming relatively stable in two-day-old flies. Most of the pyruvate kinase activity of adults is found in the thorax.



Publications
Articles associated with genes and sequences of this homology group.

M2 isoform of pyruvate kinase is dispensable for tumor maintenance and growth.
Cortés-Cros M, et al. Proc Natl Acad Sci U S A 110, 489-94 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
PLN02461 (PLN02461)
  Probable pyruvate kinase.
pyruv_kin (TIGR01064)
  pyruvate kinase.
Pyruvate_Kinase (cd00288)
  Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Pkm includes H.sapiens PKM.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Actinopterygii - bony fishes (28 transcripts, 12 species)
Mammalia - mammals (27 transcripts, 15 species)
Amphibia - amphibians (13 transcripts, 2 species)
Ascidiacea - tunicates (5 transcripts, 2 species)
Aves - birds (3 transcripts, 3 species)
Hyperoartia - vertebrates (3 transcripts, 1 species)
Amniota - vertebrates (1 transcript, 1 species)
Cephalochordata - lancelets (1 transcript, 1 species)

Arthropoda
Insecta - insects (24 transcripts, 13 species)
Maxillopoda - crustaceans (2 transcripts, 1 species)
Arachnida - arachnids (1 transcript, 1 species)
Branchiopoda - crustaceans (1 transcript, 1 species)
Malacostraca - crustaceans (1 transcript, 1 species)

Platyhelminthes
Trematoda - flatworms (7 transcripts, 2 species)
Turbellaria - flatworms (6 transcripts, 1 species)

Nematoda
Chromadorea - nematodes (6 transcripts, 2 species)

Cnidaria
Hydrozoa - hydrozoans (2 transcripts, 2 species)
Anthozoa - anthozoans (1 transcript, 1 species)

Mollusca
Gastropoda - gastropods (2 transcripts, 2 species)

Annelida
Hirudinida - segmented worms (2 transcripts, 1 species)

Echinodermata
Echinoidea - sea urchins (2 transcripts, 1 species)

Porifera
Demospongiae - sponges (1 transcript, 1 species)

Streptophyta
Eudicotyledons - eudicots (56 transcripts, 28 species)
Liliopsida - monocots (25 transcripts, 9 species)
Coniferopsida - conifers (1 transcript, 1 species)

Chlorophyta
Chlorophyceae - green algae (1 transcript, 1 species)

Ascomycota
Sordariomycetes - ascomycetes (19 transcripts, 3 species)
Eurotiomycetes - ascomycetes (1 transcript, 1 species)
Pezizomycetes - ascomycetes (1 transcript, 1 species)

Basidiomycota
Heterobasidiomycetes - basidiomycetes (1 transcript, 1 species)

Bacillariophyta
Bacillariophyceae - diatoms (3 transcripts, 1 species)

Oomycetes
Peronosporales - oomycetes (1 transcript, 1 species)

Codonosigidae
Monosiga - choanoflagellates (3 transcripts, 1 species)

Apicomplexa
Coccidia - apicomplexans (1 transcript, 1 species)

Ciliophora
Oligohymenophorea - ciliates (1 transcript, 1 species)

 

 

 

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