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HomoloGene:20103. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   SERPINA1,  H.sapiens
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
    NP_001002236.1
418 aa
   SERPINA1,  P.troglodytes
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
    XP_522938.2
418 aa
   SERPINA1,  M.mulatta
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
    XP_001099255.1
418 aa
   SERPINA1,  C.lupus
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
    NP_001073578.1
415 aa
   SERPINA1,  B.taurus
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
    NP_776307.1
416 aa
   Serpina1e,  M.musculus
serine (or cysteine) peptidase inhibitor, clade A, member 1E
    NP_033273.1
413 aa
   Serpina1a,  M.musculus
serine (or cysteine) peptidase inhibitor, clade A, member 1A
    NP_033269.1
413 aa
   Serpina1c,  M.musculus
serine (or cysteine) peptidase inhibitor, clade A, member 1C
    NP_033271.1
413 aa
   Serpina1b,  M.musculus
serine (or cysteine) preptidase inhibitor, clade A, member 1B
    NP_033270.3
413 aa
   Serpina1d,  M.musculus
serine (or cysteine) peptidase inhibitor, clade A, member 1D
    NP_033272.1
413 aa
   Serpina1,  R.norvegicus
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
    NP_071964.2
411 aa
   SERPINA4,  G.gallus
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4
    NP_001264421.1
425 aa
   SERPINA9,  G.gallus
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 9
    XP_004941955.1
432 aa
   SERPINA1,  G.gallus
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
    NP_001264422.1
425 aa
   SERPINA5,  G.gallus
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
    XP_004941954.1
447 aa
   serpina3k,  X.tropicalis
serine (or cysteine) proteinase inhibitor, clade A, member 3K
    XP_002936116.2
432 aa
   serpina1,  X.tropicalis
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
    XP_002936109.1
437 aa
   LOC100488834,  X.tropicalis
alpha-1-antiproteinase 2-like
    XP_002936115.2
432 aa
   serpina1l,  D.rerio
serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1, like
    NP_001013277.3
433 aa
   serpina1,  D.rerio
serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
    NP_001071226.1
429 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Emphysema.
Emphysema-cirrhosis.
Hemorrhagic diathesis due to `antithrombin' Pittsburgh.
Pulmonary disease, chronic obstructive, susceptibility to.



Publications
Articles associated with genes and sequences of this homology group.

Identification and characterization of α1 -antitrypsin in fibrin clots.
Talens S, et al. J Thromb Haemost 11, 1319-28 (2013).
[Serum A1-antitrypsin levels in prostate pathology].
Dokrunova AA & Sokolova OS. Urologiia, 77-80 (2012).
Alpha 1-antitrypsin. A novel biomarker for obesity in humans.
Xue GB, et al. Saudi Med J 34, 34-9 (2013).
[Genetic variants of alpha-1 antitrypsin: classification and clinical implications].
Popławska B, et al. Pneumonol Alergol Pol 81, 45-54 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
SERPIN (cl00137)
  SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Serpina1a includes H.sapiens SERPINA1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (18 transcripts, 13 species)
Actinopterygii - bony fishes (9 transcripts, 7 species)
Aves - birds (2 transcripts, 1 species)
Amniota - vertebrates (1 transcript, 1 species)

 

 

 

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