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HomoloGene:7314. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   PTK2,  H.sapiens
protein tyrosine kinase 2
    NP_005598.3
1074 aa
   PTK2,  P.troglodytes
PTK2 protein tyrosine kinase 2
    XP_519982.2
1074 aa
   PTK2,  M.mulatta
PTK2 protein tyrosine kinase 2
    XP_001093060.2
1074 aa
   PTK2,  C.lupus
protein tyrosine kinase 2
    XP_005628050.1
1112 aa
   PTK2,  B.taurus
PTK2 protein tyrosine kinase 2
    NP_001068718.2
1061 aa
   Ptk2,  M.musculus
PTK2 protein tyrosine kinase 2
    NP_032008.2
1052 aa
   Ptk2,  R.norvegicus
protein tyrosine kinase 2
    NP_037213.1
1055 aa
   PTK2,  G.gallus
PTK2 protein tyrosine kinase 2
    NP_990766.1
1053 aa
   ptk2,  X.tropicalis
protein tyrosine kinase 2
    XP_002934523.2
1125 aa
   ptk2ab,  D.rerio
protein tyrosine kinase 2ab
    NP_571871.1
1050 aa
   Fak,  D.melanogaster
Focal adhesion kinase
    NP_001137719.2
1200 aa
   AgaP_AGAP011118,  A.gambiae
AgaP_AGAP011118
    XP_309528.4
1077 aa
   kin-32,  C.elegans
kin-32
    NP_740841.1
867 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

FAK-heterozygous mice display enhanced tumour angiogenesis.
Kostourou V, et al. Nat Commun 4, 2020 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Focal_AT (pfam03623)
  Focal adhesion targeting region.
B41 (smart00295)
  Band 4.1 homologues.
FERM_M (pfam00373)
  FERM central domain.
PKc_like (cl09925)
  Protein Kinases, catalytic domain.
FERM_M (pfam00373)
  FERM central domain.
PKc_like (cl09925)
  Protein Kinases, catalytic domain.
PH-like (cl17171)
  Pleckstrin homology-like domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Ptk2 includes H.sapiens PTK2 and R.norvegicus Ptk2.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (20 transcripts, 14 species)
Actinopterygii - bony fishes (20 transcripts, 8 species)
Amphibia - amphibians (3 transcripts, 2 species)
Aves - birds (2 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)
Ascidiacea - tunicates (1 transcript, 1 species)

Arthropoda
Insecta - insects (6 transcripts, 5 species)
Arachnida - arachnids (1 transcript, 1 species)
Branchiopoda - crustaceans (1 transcript, 1 species)
Maxillopoda - crustaceans (1 transcript, 1 species)

Cnidaria
Hydrozoa - hydrozoans (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (1 transcript, 1 species)

 

 

 

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