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HomoloGene:227. Gene conserved in Opisthokonta Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   PNP,  H.sapiens
purine nucleoside phosphorylase
    NP_000261.2
289 aa
   PNP,  P.troglodytes
purine nucleoside phosphorylase
    XP_001140576.1
289 aa
   LOC710245,  M.mulatta
purine nucleoside phosphorylase-like
    XP_001104622.1
289 aa
   PNP,  C.lupus
purine nucleoside phosphorylase
    XP_532617.2
289 aa
   PNP,  B.taurus
purine nucleoside phosphorylase
    NP_001007819.1
289 aa
   LOC790312,  B.taurus
purine nucleoside phosphorylase-like
    XP_002690791.3
304 aa
   Pnp2,  M.musculus
purine-nucleoside phosphorylase 2
    NP_001116843.1
305 aa
   Pnp,  M.musculus
purine-nucleoside phosphorylase
    NP_038660.1
289 aa
   Pnp,  R.norvegicus
purine nucleoside phosphorylase
    NP_001099501.1
216 aa
   PNP,  G.gallus
purine nucleoside phosphorylase
    XP_003641950.2
308 aa
   pnp,  X.tropicalis
purine nucleoside phosphorylase
    NP_001006720.1
297 aa
   CG16758,  D.melanogaster
CG16758
    NP_001261330.1
396 aa
   AgaP_AGAP005945,  A.gambiae
AgaP_AGAP005945
    XP_001688760.1
353 aa
   AgaP_AGAP005944,  A.gambiae
AgaP_AGAP005944
    XP_315978.4
329 aa
   K02D7.1,  C.elegans
K02D7.1
    NP_499900.1
301 aa
   PNP1,  S.cerevisiae
PNP1
    NP_013310.1
311 aa
   KLLA0C16621g,  K.lactis
KLLA0C16621g
    XP_452943.1
306 aa
   AGOS_ACR198W,  E.gossypii
AGOS_ACR198W
    NP_983600.1
308 aa
   SPAC1805.16c,  S.pombe
SPAC1805.16c
    NP_593927.1
315 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Nucleoside phosphorylase deficiency, immunodeficiency due to.



Publications
Articles associated with genes and sequences of this homology group.

T- and B-cell defects in a novel purine nucleoside phosphorylase mutation.
Somech R, et al. J Allergy Clin Immunol 130, 539-42 (2012).
Cerebellar abnormalities in purine nucleoside phosphorylase deficient mice.
Mansouri A, et al. Neurobiol Dis 47, 201-9 (2012).
Purine nucleoside phosphorylase deficiency: a mutation update.
Walker PL, et al. Nucleosides Nucleotides Nucleic Acids 30, 1243-7 (2011).
Effects of purine nucleoside phosphorylase deficiency on thymocyte development.
Papinazath T, et al. J Allergy Clin Immunol 128, 854-863.e1 (2011).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
PNP_UDP_1 (cl00303)
  Phosphorylase superfamily.
PNP_UDP_1 (cl00303)
  Phosphorylase superfamily.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Pnp includes H.sapiens PNP.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (20 transcripts, 12 species)
Actinopterygii - bony fishes (13 transcripts, 7 species)
Amphibia - amphibians (2 transcripts, 2 species)
Cephalochordata - lancelets (1 transcript, 1 species)

Arthropoda
Insecta - insects (14 transcripts, 11 species)
Arachnida - arachnids (2 transcripts, 1 species)
Branchiopoda - crustaceans (1 transcript, 1 species)
Malacostraca - crustaceans (1 transcript, 1 species)
Maxillopoda - crustaceans (1 transcript, 1 species)

Mollusca
Gastropoda - gastropods (3 transcripts, 2 species)

Nematoda
Chromadorea - nematodes (2 transcripts, 2 species)

Porifera
Demospongiae - sponges (2 transcripts, 1 species)

Platyhelminthes
Trematoda - flatworms (2 transcripts, 2 species)

Cnidaria
Hydrozoa - hydrozoans (1 transcript, 1 species)

Annelida
Hirudinida - segmented worms (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (1 transcript, 1 species)

Ascomycota
Eurotiomycetes - ascomycetes (1 transcript, 1 species)
Pezizomycetes - ascomycetes (1 transcript, 1 species)

 

 

 

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