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HomoloGene:31000. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   PTGS2,  H.sapiens
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
    NP_000954.1
604 aa
   PTGS2,  P.troglodytes
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
    XP_524999.3
604 aa
   PTGS2,  M.mulatta
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
    XP_001107538.2
604 aa
   PTGS2,  C.lupus
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
    NP_001003354.1
604 aa
   PTGS2,  B.taurus
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
    NP_776870.1
604 aa
   Ptgs2,  M.musculus
prostaglandin-endoperoxide synthase 2
    NP_035328.2
604 aa
   Ptgs2,  R.norvegicus
prostaglandin-endoperoxide synthase 2
    NP_058928.3
604 aa
   PTGS2,  G.gallus
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
    NP_001161191.1
603 aa
   ptgs2,  X.tropicalis
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
    NP_001025697.1
604 aa
   ptgs2b,  D.rerio
prostaglandin-endoperoxide synthase 2b
    NP_001020675.1
606 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

ROS dependence of cyclooxygenase-2 induction in rats subjected to unilateral ureteral obstruction.
Ostergaard M, et al. Am J Physiol Renal Physiol 306, F259-70 (2014).
Renal effects induced by prolonged mPGES1 inhibition.
Salazar F, et al. Am J Physiol Renal Physiol 306, F68-74 (2014).
[Evaluation of COX-2 protein expression in melanocytic nevi in children].
Kubus M, et al. Pol Merkur Lekarski 35, 82-4 (2013).
Pre-existent asymmetry in the human cyclooxygenase-2 sequence homodimer.
Dong L, et al. J Biol Chem 288, 28641-55 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
EGF_CA (cl09941)
  Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
An_peroxidase_like (cl14561)
  Animal heme peroxidases and related proteins.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Ptgs2 includes H.sapiens PTGS2 and R.norvegicus Ptgs2.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (15 transcripts, 13 species)
Actinopterygii - bony fishes (15 transcripts, 10 species)
Ascidiacea - tunicates (3 transcripts, 2 species)
Amphibia - amphibians (2 transcripts, 2 species)
Aves - birds (1 transcript, 1 species)
Cephalochordata - lancelets (1 transcript, 1 species)
Hyperoartia - vertebrates (1 transcript, 1 species)

Cnidaria
Hydrozoa - hydrozoans (1 transcript, 1 species)

 

 

 

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