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HomoloGene:69472. Gene conserved in Eukaryota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   SLC26A5,  H.sapiens
solute carrier family 26 (anion exchanger), member 5
    NP_945350.1
744 aa
   SLC26A5,  P.troglodytes
solute carrier family 26, member 5 (prestin)
    XP_003339466.1
744 aa
   SLC26A5,  C.lupus
solute carrier family 26 (anion exchanger), member 5
    XP_540393.2
744 aa
   SLC26A5,  B.taurus
solute carrier family 26, member 5 (prestin)
    NP_001179807.1
741 aa
   Slc26a5,  M.musculus
solute carrier family 26, member 5
    NP_109652.3
744 aa
   Slc26a5,  R.norvegicus
solute carrier family 26 (anion exchanger), member 5
    NP_110467.1
744 aa
   SLC26A5,  G.gallus
solute carrier family 26, member 5 (prestin)
    NP_001072945.1
742 aa
   slc26a5,  X.tropicalis
solute carrier family 26, member 5 (prestin)
    XP_002933151.2
754 aa
   slc26a5,  D.rerio
solute carrier family 26, member 5
    NP_958881.1
739 aa
   Prestin,  D.melanogaster
Prestin
    NP_649024.1
742 aa
   AgaP_AGAP010389,  A.gambiae
AgaP_AGAP010389
    XP_559067.3
645 aa
   sulp-7,  C.elegans
sulp-7
    NP_001033571.1
582 aa
   sulp-8,  C.elegans
sulp-8
    NP_001256129.1
611 aa
   sulp-5,  C.elegans
sulp-5
    NP_505990.2
725 aa
   sulp-4,  C.elegans
sulp-4
    NP_505989.1
749 aa
   sulp-3,  C.elegans
sulp-3
    NP_509424.2
782 aa
   AST91,  A.thaliana
AST91
    NP_173722.1
631 aa
   Os04g0652400,  O.sativa
Os04g0652400
    NP_001054098.1
661 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Deafness, autosomal recessive 61.



Publications
Articles associated with genes and sequences of this homology group.

Mammalian prestin is a weak Cl⁻/HCO₃⁻ electrogenic antiporter.
Mistrík P, et al. J Physiol 590, 5597-610 (2012).
Prestin in HEK cells is an obligate tetramer.
Hallworth R & Nichols MG. J Neurophysiol 107, 5-11 (2012).
Expression analysis of prestin and selected transcription factors in newborn rats.
Gross J, et al. Cell Mol Neurobiol 31, 1089-101 (2011).
Evidence that prestin has at least two voltage-dependent steps.
Homma K & Dallos P. J Biol Chem 286, 2297-307 (2011).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
sulP (TIGR00815)
  high affinity sulphate transporter 1.
Sulfate_tra_GLY (pfam13792)
  Sulfate transporter N-terminal domain with GLY motif.
Sulfate_transp (pfam00916)
  Sulfate transporter family.
STAS (cl00604)
  Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors.
Sulfate_tra_GLY (pfam13792)
  Sulfate transporter N-terminal domain with GLY motif.
STAS (cl00604)
  Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors.
Sulfate_transp (cl19250)
  Sulfate transporter family.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Slc26a5 includes H.sapiens SLC26A5 and R.norvegicus Slc26a5.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Streptophyta
Eudicotyledons - eudicots (38 transcripts, 26 species)
Liliopsida - monocots (12 transcripts, 8 species)
Coniferopsida - conifers (4 transcripts, 3 species)
Bryopsida - mosses (1 transcript, 1 species)

Chordata
Actinopterygii - bony fishes (7 transcripts, 7 species)
Mammalia - mammals (6 transcripts, 6 species)
Ascidiacea - tunicates (3 transcripts, 2 species)
Aves - birds (1 transcript, 1 species)
Amphibia - amphibians (1 transcript, 1 species)

Arthropoda
Insecta - insects (5 transcripts, 5 species)
Arachnida - arachnids (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (6 transcripts, 2 species)

Mollusca
Gastropoda - gastropods (2 transcripts, 2 species)

Platyhelminthes
Trematoda - flatworms (1 transcript, 1 species)

Annelida
Polychaeta - segmented worms (1 transcript, 1 species)

 

 

 

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