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HomoloGene:816. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   SLC6A2,  H.sapiens
solute carrier family 6 (neurotransmitter transporter), member 2
    NP_001165972.1
617 aa
   SLC6A2,  P.troglodytes
solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2
    XP_001167725.1
617 aa
   SLC6A2,  M.mulatta
solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2
    NP_001028195.1
617 aa
   SLC6A2,  C.lupus
solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2
    NP_001129974.1
617 aa
   SLC6A2,  B.taurus
solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2
    NP_777033.1
615 aa
   Slc6a2,  M.musculus
solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2
    NP_033235.3
617 aa
   Slc6a2,  R.norvegicus
solute carrier family 6 (neurotransmitter transporter), member 2
    NP_112633.1
597 aa
   SLC6A2,  G.gallus
solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2
    NP_990047.1
635 aa
   slc6a2,  X.tropicalis
solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2
    XP_002939272.2
576 aa
   LOC565776,  D.rerio
sodium-dependent noradrenaline transporter-like
    XP_694138.3
625 aa
   DAT,  D.melanogaster
Dopamine transporter
    NP_523763.2
631 aa
   AgaP_AGAP007367,  A.gambiae
AgaP_AGAP007367
    XP_308462.4
665 aa
   dat-1,  C.elegans
dat-1
    NP_499043.1
615 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Orthostatic intolerance.



Publications
Articles associated with genes and sequences of this homology group.

Kinetics of the dopamine transporter in Drosophila larva.
Vickrey TL, et al. ACS Chem Neurosci 4, 832-7 (2013).
Epigenetic modification of the norepinephrine transporter gene in postural tachycardia syndrome.
Bayles R, et al. Arterioscler Thromb Vasc Biol 32, 1910-6 (2012).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
SLC5-6-like_sbd (cl00456)
  Solute carrier families 5 and 6-like; solute binding domain.
SLC5-6-like_sbd (cl00456)
  Solute carrier families 5 and 6-like; solute binding domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Slc6a2 includes H.sapiens SLC6A2 and R.norvegicus Slc6a2.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (8 transcripts, 7 species)
Actinopterygii - bony fishes (2 transcripts, 2 species)
Ascidiacea - tunicates (1 transcript, 1 species)
Aves - birds (1 transcript, 1 species)

Arthropoda
Insecta - insects (6 transcripts, 5 species)
Arachnida - arachnids (1 transcript, 1 species)

Mollusca
Gastropoda - gastropods (3 transcripts, 2 species)

Nematoda
Chromadorea - nematodes (2 transcripts, 2 species)

Platyhelminthes
Trematoda - flatworms (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (1 transcript, 1 species)

 

 

 

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